Email this article Molecular, biological and diagnostic features of Ewing sarcoma and undifferentiated small round cell sarcomas of bone and soft tissue
- Authors: Sinichenkova K.Y.1, Roschin V.Y.1, Druy A.E.1
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Affiliations:
- Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology, Ministry of Healh of Russia
- Issue: Vol 13, No 1 (2021)
- Pages: 24-31
- Section: BONE SARCOMAS
- Published: 02.06.2021
- URL: https://sarbon.abvpress.ru/jour/article/view/110
- DOI: https://doi.org/10.17650/2070-9781-2021-13-1-24-31
- ID: 110
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Abstract
Ewing’s sarcoma is a highly malignant small round cell tumor with a unique rearrangement of the EWSR1 (FUS) gene with partners genes of ETS family. Tumors with Ewing's sarcoma morphological features lacking without specific EWSR1 rear-rangement called undifferentiated small round cell sarcomas of bone and soft tissue. This group includes: sarcomas with СIC gene rearrangement, sarcomas with BCOR gene rearrangement and sarcomas with EWSR1 (FUS) gene rearrangement with non-ETS gene-partner. Clinical, morphological and molecular genetic characteristics of these groups of tumors will be described below
About the authors
K. Y. Sinichenkova
Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology, Ministry of Healh of Russia
Author for correspondence.
Email: ksinichenkova@gmail.com
ORCID iD: 0000-0002-1661-4205
1 Samory Mashela St., Moscow 117198
Russian FederationV. Y. Roschin
Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology, Ministry of Healh of Russia
ORCID iD: 0000-0002-9375-7517
1 Samory Mashela St., Moscow 117198
Russian FederationA. E. Druy
Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology, Ministry of Healh of Russia
ORCID iD: 0000-0003-1308-8622
1 Samory Mashela St., Moscow 117198
Russian FederationReferences
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