The combined treatment oflocally advanced soft tissue. Sarcomas (STS)

115 patients with locally advanced STS treated in MRRC RAMS were analyzed. In group 1 were included 32 patients who received preoperative thermo-chemo-radiotherapy (TCRT) and surgery with intraoperative radiation therapy (IORT). The group 2 consisted of 31 patients treated with preoperative chemo-radiotherapy (CRT) followed by surgery with IORT. The group 3 included 22 patients received TCRT, without surgery. The control group consisted of 30 patients treated with surgery only. IORT didn’t increase an incidence of postoperative complications. None of the patients in group 1 had local recurrence during 5 years. The locoregional-recurrence-free-survival (LRFS), metastasis-free survival and overall survival rates (86-100%, 70-49%, 80-64%) at 5 years were higher in groups with IORT compared to the control (32, 18, 25,5%). Rates of recurrence in group 3 (TCRT) didn’t differ significantly from the control during the first 4 years, moreover, the first year LRFS was even higher (p=0,05).

sarcomas of the soft tissues, combined treatment, intraoperative radiation therapy, thermo-chemo-radiotherapy