Infantile fibrosarcoma: a clinicopathologic analysis ofl5 cases

The diagnosis of infantile fibrosarcoma was made retrospectively in 15 patients. Follow up showed 4 recurrences, no metastases and death during 1-3 years. The lesion were 2-8 cm; occured in the upper and lower extremities, trunk and head. Patients had a long history of painless intramuscular mass (median duration 3 month). All tumors are finely sclerotic, containing nests of fibroblasts with clear cytoplasm and bland cytologic features of nuclei. Areas of spindled cells with nuclear enlargement and hyperchromatism were identified. No necrosis and mitotic activity less than 4 mf/10 HPF were present. Ultrastructurally, the tumor composed of neoplastic fibroblasts. No other cell differentiation were identified. We discuss the overlapping clinicopathologic features and differences between infantile fibrosarcoma and adult fibrosarcoma.

infantile fibrosarcoma, histopathology, ultra structure, clinical features