Role of receptor-ligand system in giant cell tumor

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Abstract

Expression of VEGF and its receptors and proliferative activities were studied in cells of giant cell tumor of the bone. Immuno-histochemical analysis was performed on 11 formalin-fixed, formalin-embedded samples of giant cell tumor of the bone. VEGF and its receptors VEGFR-1 (Flt-1) and VEGFR-2 (Flk-l/KDR) was detected in all specimens and all cellular components such as reactive osteoclast-like giant cells and stromal cells. Ki-67 expression was limited to the mononuclear stromal cell component of the tumors. The high degree of expression Flk-1 and Flt-1 significantly correlated with high proliferative activity of the tumor (≥5 %) (p=0,031 for Flk-1 and p=0,048 for Flt-1). These results suggest that VEGF receptor-ligand system might play a role in the pathogenesis of giant cell tumor of the bone. The further research should help to explain a unique nature and cell interaction mechanisms of this tumor.

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E. V. Stepanova

N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences

Author for correspondence.
Email: e_stepanova@nm.ru
Russian Federation

E. R. Musaev

N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences

Russian Federation

E. A. Sushencov

N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences

Russian Federation

N. N. Petrovichev

N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences

Russian Federation

M. D. Aliev

N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences

Russian Federation

M. R. Lichinizer

N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences

Russian Federation

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Copyright (c) 2010 Stepanova E.V., Musaev E.R., Sushencov E.A., Petrovichev N.N., Aliev M.D., Lichinizer M.R.

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