Clinical research of histological subtypes of the vulvar sarcomas: prospective trial

Background. Vulvar sarcomas (VS) are very rare tumors with a frequency of less than 1-2 % from total number of malignant tumors of a vulva. VS arise in female of a wide age range. Materials and methods. We present the clinicopathologic and immunohistochemical features of 4 cases seen in our institution over a period of 5 years (between January, 1st 2006 and April, 30th, 2010). This is a review of the prospective clinical research of patients with vulvar sarcoma, consisting of endometrioid stromal sarcomas (n=2), primary vulvar Ewing’s sarcoma (n=l), aggressive angiomyxoma (n=l). Results. Anamnestic, diagnostic, morphological data, characteristics and results of treatment of patients with subtypes of VS are presented taking into account features of morphological characteristics. All patients have received the surgical, combined, complex treatment in N.N. Blokhin Russian Cancer Research Center. The analysis is carried out in the presented group VS with rare morphological subtypes taking into account different aggression. Conclusion. Sarcoma of the vulva in adults is often published as a case report, given their very infrequent occurrence. Acknowledging and correctly applying restrictions and advantages of such researches which do not belong to «the gold standard» type, it is nevertheless quite possible to apply successfully the saved up data for the development of medical science and for practical public health services.

vulva, sarcoma