Breast sarcomas and phyllodes tumors. Clinical and genetic features

Complex research which helps to answer a part of the questions, concerning phyllodes tumors treatment diagnostics was carried out. These tumors are characterized as tumors that have a two component structure with the predominant development of mesenchymal component, which in sarcomas is the absolute part. In molecular genetic position it is shown, that germinal mis-sense mutation R1699W of BRCA1 gene carriers have high probability of malignant phyllodes tumor developing and allelic losses at locus D22S264 ofTP5 gene determine the progression of the disease.

BRCA1/2, breast sarcoma, breast phyllodes tumors, recurrence, malignancy, and molecular-genetic markers, BRCA1/2, TP53