Molecular biomarkers oftypel neurofibromatosis

E. V. Stepanova; Степанова Е. В.; M. R. Lichinitser; Личиницер М. Р.; B. Y. Bokhyan; Бохян В. Ю.; A. A. Fedenko; Феденко А. А.; T. K. Charatishvili; Харатишвили Т. К.; M. D. Aliev; Алиев М. Д.

Molecular biomarkers oftypel neurofibromatosis

Authors: Stepanova E.V.¹, Lichinitser M.R.¹, Bokhyan B.Y.¹, Fedenko A.A.¹, Charatishvili T.K.¹, Aliev M.D.¹
Affiliations:
1. N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences
Issue: Vol 2, No 4 (2010)
Pages: 55-58
Section: EXPERIMENTAL ONCOLOGY
Published: 11.11.2010
URL: https://sarbon.abvpress.ru/jour/article/view/187
ID: 187

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Abstract

Neurofibromatosis type I is a autosomal dominant hereditary disorder caused by NF1 gene mutations. The main molecular mechanisms contributes to tumor formation in neurofibromatosis type I is angiogenesis stimulation and ras, AKT-mTOR signaling pathways activation. We show that these tumors expressed c-kit and VEGF. Information about clinical trials of target therapy for neurofibromatosis I type patient treatment is cited.