IL6, rIL-6R and general alkaline phosphotase activity in bone tumors and their role in the prognosis of disease

N. E. Kushlinsky; Кушлинский Н. Е.; T. A. Tarasova; Тарасова Т. А.; Yu. N. Solovjev; Соловьев Ю. Н.; N. V. Ljubimova; Любимова Н. В.; O. I. Kostyleva; Костылева О. И.; I. V. Bulytscheva; Булычева И. В.; G. N. Machak; Мачак Г. Н.; A. N. Machson; Махсон А. Н.; M. D. Aliev; Алиев М. Д.

IL6, rIL-6R and general alkaline phosphotase activity in bone tumors and their role in the prognosis of disease

Authors: Kushlinsky N.E.¹, Tarasova T.A.¹, Solovjev Y.N.¹, Ljubimova N.V.¹, Kostyleva O.I.¹, Bulytscheva I.V.², Machak G.N.¹, Machson A.N.², Aliev M.D.¹
Affiliations:
1. N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences
2. 62 Oncology County Hospital
Issue: Vol 2, No 4 (2010)
Pages: 59-65
Section: EXPERIMENTAL ONCOLOGY
Published: 11.11.2010
URL: https://sarbon.abvpress.ru/jour/article/view/188
ID: 188

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Abstract

The comparative analysis of IL-6, rIL-6R levels and of general AP activity in blood serum of 159 patients with different malignant and benign bone tumors was carried out. Medians of serum IL-6 levels were found significantly higher in bone sarcomas (5,3 pg/ml), benign tumors (3,2 pg/ml) and also in giant cell tumors (GCT) (3,9 pg/ml) than in control group (1,2 pg/ml, p=0,0001). The highest IL-6 levels were observed in malignant fibrous histiocytomas (MFH) and also in Ewing's sarcomas. As for IL-6 receptors, no differences were observed in rIL-6R levels among bone sarcomas, benign bone tumors and also GCT. The reverse correspondence between initial rIL-6R serum levels (before treatment), treatment pathomorphosis and malignancy level were demonstrated in EwS and OS. rIL-6R serum levels correlated positively with tumor size (T) especially in chondrosarcomas (ChS). Also the positive correlation was shown between general AP activity and both of tumor size and metastasizing (p=0,02) and additionally malignancy level in patients with bone sarcomas. Reliable differences were found in AP serum activity between benign and malignant bone neoplasms. Combination of IL-6 level and of general AP activity was evaluated as the most significant for relapse-free survival prognosis in patients with bone sarcomas by multifactor analysis.

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IL-6, rIL-6R, AP, prognosis, bone sarcomas, blood serum

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IL6, rIL-6R and general alkaline phosphotase activity in bone tumors and their role in the prognosis of disease

Full Text

Abstract

Keywords

About the authors

References

Supplementary files