Rationale for clinical study of preoperative treatment of soft tissue sarcomas
with local ultrasound hyperthermia and chemotherapy with cisplatin and/ or
doxorubicin

Андронова Н. В.; Бохян Б. Ю.; Николаев А. Л.; Трещалина Е. М.; Алиев М. Д.; Филоненко Д. В.; Гопин А. В.; Божевольнов В. Е.; Коган Б. Я.; Ворожцов Г. Н.; N. V. Andronova; B. Yu. Bokhyan; A. L. Nikolaev; E. M. Treshalina; M. D. Aliev; D. V. Filonenko; A. V. Gopin; V. E. Bozhevolnov; B. Ya. Kogan; G. N. Vorozhtcov

Rationale for clinical study of preoperative treatment of soft tissue sarcomas with local ultrasound hyperthermia and chemotherapy with cisplatin and/ or doxorubicin

Authors: ¹, ¹, ², ¹, ¹, ¹, ², ², ³, ³, Andronova N.V.⁴, Bokhyan B.Y.⁴, Nikolaev A.L.⁵, Treshalina E.M.⁴, Aliev M.D.⁴, Filonenko D.V.⁴, Gopin A.V.⁵, Bozhevolnov V.E.⁵, Kogan B.Y.⁶, Vorozhtcov G.N.⁶
Affiliations:
1. Российский онкологический научный центр им. Н.Н. Блохина РАМН
2. Московский государственный университет им. Н.В. Ломоносова
3. ФГУП Государственный научный центр «НИОПИК»
4. N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Science
5. Moscow State University
6. State Research Center NIOPIK
Issue: Vol 3, No 1 (2011)
Pages: 28-33
Section: Articles
Published: 11.01.2011
URL: https://sarbon.abvpress.ru/jour/article/view/195
ID: 195

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Abstract

The aim of the study was to obtain experimental data on the specific antitumor activity of the thermochemotherapy (TCT), which combines local ultrasound hyperthermia and chemotherapy with cisplatin and doxorubicin. Material and methods. The experiments were performed on mice with murine intramuscular transplanted hematogenic metastatic tumors Lewis lung carcinoma LLC and melanoma B16 with average volume of 0,6-1,1 cm³. Local ultrasound hyperthermia (US-HT) was performed on the original ultrasonic device USDT-m with ultrasound of two frequencies (0,88 and 2,64 MHz) simultaneously with a maximum intensity of 2,5-3,0 W/cm² in the temperature range 41,5-43 °C. Ultrasonic treatment was carried out after systemic chemotherapy with cisplatin (CP) and doxorubicin (Dox). Results. It was shown that local ultrasound hyperthermia and chemotherapy with cisplatin and doxorubicin allows to reduce the size of the tumor in 3-3,5 times, depending on tumor size and dose of cytostatics, with a satisfactory tolerability of treatment. Conclusion. The obtained results suggest a clinical trial of the TCT method with usage of USDT-m promising for preoperative treatment of patients with soft tissue sarcoma in order to achieve operability through cytoreduction of tumor mass.