Thermo-chemo-radio-therapy in the combined
treatment of locally advanced soft tissue sarcomas (STS)

Зубарев Л. А.; Курильчик А. А.; Кудрявцева Г. Т.; Курпешев О. К.; Ста- Родубцев А. Л.; Иванов В. Е.; A. L. Zubarev; A. A. Kurilchik; G. T. Kudryavtseva; O. K. Kurpeshev; A. L. Starodub- Tsev; V. E. Ivanov

Thermo-chemo-radio-therapy in the combined treatment of locally advanced soft tissue sarcomas (STS)

Authors: ¹, ¹, ¹, ¹, ¹, ¹, Zubarev A.L.², Kurilchik A.A.², Kudryavtseva G.T.², Kurpeshev O.K.², Starodub- Tsev A.L.², Ivanov V.E.²
Affiliations:
1. ФГБУ Медицинский радиологический научный центр Минздравсоцразвития РФ
2. FMMS Medical Radiological Research Centre MH &PD RF
Issue: Vol 3, No 1 (2011)
Pages: 34-38
Section: Articles
Published: 11.01.2011
URL: https://sarbon.abvpress.ru/jour/article/view/196
ID: 196

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Abstract

118 patients with locally advanced STS examined and treated in MRRC were analyzed. In group 1 were included 31 patients treated by only surgery (S). The group 2 consisted of 33 patients treated with preoperative chemo-radiotherapy (CRT) followed by S. The group 3 included 22 patients received preoperative thermo-chemo-radiotherapy (TCRT) and S. The group 4 consisted of 32 patients, who received preoperative TCRT and S with intraoperative radiation therapy (IORT). Preoperative TCRT increased number of patients with stage III & IV of tumor therapeutic pathomorphism. TCRT and IORT didn't increase an incidence of complications and allowed to perform an increase organ-saving operations. None of the patients in group with TCRT had local recurrence during 3-5 years. The locoregional-recurrence-free-survival (LRFS), metastasis-free survival and overall survival rates (73-100, 56-88, 68-95%) were higher in group with combined treatment compared to first group (30, 20,5, 29%) respectively.