Сartilaginous bone tumors and matix metalloproteinases
1, 2, 9

Булычева И. В.; Кушлинский Н. Е.; Соловьев Ю. Н.; Тен Е. А.; Дворова Е. К.; Махсон А. Н.; I. V. Boulytcheva; N. E. Kushlinsky; Yu. N. Soloviev; E. A. Ten; E. K. Dvorova; A. N. Makhson

Сartilaginous bone tumors and matix metalloproteinases 1, 2, 9

Authors: ¹, ², ², ², ², ¹, Boulytcheva I.V.³, Kushlinsky N.E.⁴, Soloviev Y.N.⁴, Ten E.A.⁴, Dvorova E.K.⁴, Makhson A.N.³
Affiliations:
1. Отделение патологической анатомии Московской онкологической больницы № 62
2. Российский онкологический научный центр им. Н.Н. Блохина РАМН
3. Pathology Department Moscow oncology hospital № 62
4. N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences
Issue: Vol 3, No 1 (2011)
Pages: 44-49
Section: Articles
Published: 11.01.2011
URL: https://sarbon.abvpress.ru/jour/article/view/198
ID: 198

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Abstract

The expression levels of MMP-1,-2,-9 has been investigated in 10 benign cartilaginous tumors (osteochondroma - 5, chondroma - 5) and 39 chondrosarcomas (classic central - 14, periosteal - 4, dedifferentiated - 7, secondary - 14). The matrix metalloproteinase expression was negative in all examined benign human cartilaginous bone tumors. Our study have shown significant positive expression of metalloproteinase in chondrosarcoma cells: MMP-1 in 84,6% of cases, MMP-2 in 73,7 % of cases, MMP-9 in 97,4% of cases with the expression levels from 10 to 60%. No correlation was found between MMP-1 levels and gender of the patient, size and grade of the tumor, but correlate with the age. Expression of MMP-1 was more prominent in central and dedifferentiated chondrosarcomas. The levels of MMP-1(+) are closely associated with 3 year free survival and 5 year overall survival rate. The MMP-1 expression suggested aggressive behavior of the tumor. MMP-2 expression in chondrosaromas did not reflect clinical features, histological grade and variations of the tumor, and did not show prognostic value. MMP-9 expression correlate with the grade and size of the tumor (T criteria). MMP-9 expression more than 40% highly correlate with poor prognosis, less than 40% express positive factor for the 3 year free survival. The size of the tumor T3 in combination with MMP-9 expression more than 40% was considered a risk factor for relapse within

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2, 9

About the authors

Отделение патологической анатомии Московской онкологической больницы № 62

Author for correspondence.
Russian Federation

Российский онкологический научный центр им. Н.Н. Блохина РАМН

Email: biochimia@mtv-net.ru
Russian Federation

Российский онкологический научный центр им. Н.Н. Блохина РАМН

Russian Federation

Российский онкологический научный центр им. Н.Н. Блохина РАМН

Russian Federation

Российский онкологический научный центр им. Н.Н. Блохина РАМН

Russian Federation

Отделение патологической анатомии Московской онкологической больницы № 62

Russian Federation

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