Alkylguanine-DNA alkyltransferase as predictive factor of efficacy of dacarbazine+cisplatin+nidran regimen in patients with metastatic skin mela- noma

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Abstract

Background. The goal of this study was to analyze significance of AGT expression as predictive marker of efficacy of Dacar bazine+Cisplatin+Nidran regimen in patients with metastatic skin melanoma Methods. 26 patients with metastatic skin melanoma were enrolled in the retrospective study. Immunohistochemical analysis of AGT expression was performed on paraffin-embedded tissue sections of primary tumor or available metastasis. Results. High AGT expression in tumor cells was associated with low efficacy of Dacarbazine+Cisplatin+Nidran regimen. Disease progression was observed in 85,7% patient with AGT-positive tumor and 29,4% - AGT-negative (р=0,023). There was a not significant difference of time without progression between two groups of patients. Conclusion. AGT expression could be potentially useful tool for predicting response of metastatic melanoma patients to Dacarbazine+Cisplatin+Nidran regimen.

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Российский онкологический научный центр им. Н.Н. Блохина РАМН

Author for correspondence.
Email: e_stepanova@nm.ru
Russian Federation

Российский онкологический научный центр им. Н.Н. Блохина РАМН

Russian Federation

Российский онкологический научный центр им. Н.Н. Блохина РАМН

Russian Federation

Российский онкологический научный центр им. Н.Н. Блохина РАМН

Russian Federation

E. V. Stepanova

N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Science

Russian Federation

M. E. Abramov

N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Science

Russian Federation

A. Yu. Baryshnikov

N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Science

Russian Federation

M. R. Lichinitser

N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Science

Russian Federation

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Copyright (c) 2011 ., ., ., ., Stepanova E.V., Abramov M.E., Baryshnikov A.Y., Lichinitser M.R.

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