Interferon a and γ in the serum of primary bone tumors patients

Бабкина И. В.; Кушлинский Н. Е.; Соловьев Ю. Н.; Костьлева О. И.; Ма- Чак Г. Н.; Алиев М. Д.; I. V. Babkina; N. E. Kushlinsky; Yu. N. Soloviev; O. I. Kostileva; G. N. Machak; M. D. Aliev

Interferon a and γ in the serum of primary bone tumors patients

Authors: ¹, ¹, ¹, ¹, ¹, ¹, Babkina I.V.², Kushlinsky N.E.², Soloviev Y.N.², Kostileva O.I.², Machak G.N.², Aliev M.D.²
Affiliations:
1. Российский онкологический научный центр им. Н.Н. Блохина РАМН
2. N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences
Issue: Vol 3, No 1 (2011)
Pages: 55-58
Section: Articles
Published: 11.01.2011
URL: https://sarbon.abvpress.ru/jour/article/view/200
ID: 200

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Abstract

Serum levels of interferon γ (IF-γ) in healthy donors and in patients with benign bone neoplasms were significantly high comparing to borderline and malignant bone tumors. No reliable distinguishes were found between serum levels of IF-α in patients with benign, borderline and malignant bone tumors. Invert correlation was shown between age and serum level of IF-α in healthy donors, on the contrary no correlations were observed between age and serum levels of IF-γ and of IF-α in patients with bone neoplasms. and also serum IF-γ and IF-α levels in patients with bone sarcomas are not dependant on the tumors histology and on the size of primary bone tumors. No correlations were found in the levels of IF-α and IF-γ in patients with localized and metastatic tumor processes. direct correlation was found between IF-α and IF-γ serum levels in patients with malignant bone tumors in condition of maximal IF-concentrations in blood serum and advanced tumors.