Analysis of risk factors for the soft tissue sarcoma relapses occurrence on the basis of tumor clinical and morphological characteristics

Background. This study was conducted to avaluate various risk factors that may influence on soft tissue sarcoma recurrences on the basis of clinical and morphological representations and quantitative statistical analysis. Materials and methods. Treatment results of 168 patients with primary soft tissue sarcomas, who received multicomponent induction and surgical treatment were analyzed. Based on the obtained data, a table of clinical and morphological factors for the prediction of sarcoma recurrence was compiled, the factors were included into groups that exert an influence on the occurrence of relapse - strong, medium and weak. 19 independent variables were selected and on their basis the possibility of relapse was analyzed, their significance as risk factors for the recurrence of soft tissue sarcoma was assessed. Results. It has been established that it is necessary to take into account the fact that surgical operation in case of sarcoma should be planned, while treatment should be carried out in specialized centers. The obtained results allowed to determine the criteria determining the quality of surgical intervention. The choice of the boundaries of resection should be based on the notions of tumor growth and the degree of malignancy, the margin of resection should be characterized collectively by surgeons and pathomorphologists. It has been established that the margin of resection (negative or positive, R0 or R1) is a more accurate prognostic factor than its characteristic in mm. Conclusion. Most accurate factors that influenced the occurrence of relapse in patients with soft tissue sarcomas included: tumor malignancy degree; margin of resection; tumor pathomorphosis; relationship of the tumor with the bone. The results of statistical calculations confirmed the data of clinical and morphological analysis.

soft tissue sarcoma, clinic-morphological characteristics of the tumor, independent variables, risk factors, prognostic factors, relapse, pathomorphosis, margin of resection