PHARMACOKINETICS FEATURES OF CISPLATIN WITH LOCAL ULTRASOUND ON EXPERIMENTAL MODEL

Сингин А. С.; Андронова Н. В.; Бохян Б. Ю.; Алиев М. Д.; Филоненко Д. В.; Трещалина Е. М.; Николаев А. Л.; Топин А. В.; Божевольнов В. Е.; A. S. Singin; N. V. Andronova; B. U. Bohyan; M. D. Aliev; D. V. Filonenko; H. M. Treshalina; A. L. Nicolaev; A. V. Gopin; V. E. Bozevolnov

PHARMACOKINETICS FEATURES OF CISPLATIN WITH LOCAL ULTRASOUND ON EXPERIMENTAL MODEL

Authors: ¹, ¹, ¹, ¹, ¹, ¹, ¹, ¹, ¹, Singin A.S.², Andronova N.V.², Bohyan B.U.², Aliev M.D.², Filonenko D.V.², Treshalina H.M.², Nicolaev A.L.², Gopin A.V.², Bozevolnov V.E.²
Affiliations:
1. Российский онкологический научный центр им. Н.Н. Блохина РАМН
2. N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences
Issue: Vol 3, No 3 (2011)
Pages: 53-56
Section: Articles
Published: 11.07.2011
URL: https://sarbon.abvpress.ru/jour/article/view/241
ID: 241

Cite item

Full Text

Abstract
About the authors
References
Supplementary files
Statistics

Abstract

With demonstrative methods was carried out the analyzis of pharmacokinetics (PhC) parameters of cisplatin (CP, DDP) accumulation by the sonodynamic therapy (SDT) together with systemic chemotherapy and following local ultrasound irradiation (US) by new equipment USDT. It was found that the selective accumulation of platinum (Pt) in the tumor with US is 1,45 times hihger: differential accumulation factor was DAF_{tumor/blood whey} - 5,94 against 4,1 without US and DAF_{tumor/blood whey} 1,87-2,02. These data can explain the

revealed earlier phenomenon of selective increasing CP antitumor activity with combining with local US and possibilities to decreasing of common toxicity of cytostatics