MODERN APPROACHES IN THE TREATMENT OF PATIENTS WITH RHABDOMYOSARCOMA OF THE URINOGENITAL SYSTEM

Рябов А. Б.; Фигурин К. М.; Нечушкина И. В.; Жордания К. И.; Капкова О. А.; Казанцев А. П.; Керимов П. А.; Рубанский М. А.; Рыбакова Д. В.; Волкова М. А.; Матвеев В. Б.; Иванова Н. М.; Поляков В. Г.; A. B. Ryabov; K. M. Figurin; I. V. Nechushkina; K. I. Jordanya; O. A. Kapkova; A. P. Kazantsev; P. A. Kerimov; M. A. Rubanskiy; D. V. Rybakova; M. A. Volkova; V. B. Matveev; N. M. Ivanova; V. G. Polyakov

MODERN APPROACHES IN THE TREATMENT OF PATIENTS WITH RHABDOMYOSARCOMA OF THE URINOGENITAL SYSTEM

Authors: ¹, ¹, ¹, ¹, ¹, ¹, ¹, ¹, ¹, ¹, ¹, ¹, ¹, Ryabov A.B.², Figurin K.M.², Nechushkina I.V.², Jordanya K.I.², Kapkova O.A.², Kazantsev A.P.², Kerimov P.A.², Rubanskiy M.A.², Rybakova D.V.², Volkova M.A.², Matveev V.B.², Ivanova N.M.², Polyakov V.G.²
Affiliations:
1. НИИ ДОГ РОНЦ им. Н.Н.Блохина РАМН
2. Institute of pediatric oncology and hematology N.N. Blokhin cancer research center RAMS
Issue: Vol 3, No 3 (2011)
Pages: 57-65
Section: Articles
Published: 11.07.2011
URL: https://sarbon.abvpress.ru/jour/article/view/242
ID: 242

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Abstract

The modern approaches in the treatment of patients with rhabdomyosarcoma of the urinogenital system are discussed. Rhabdomyosarcoma (RMS) of the urinogenital system has benefited from near 30 years in more than 70% overall 5-year survival. Substantial progress has been made as a result of multi-center collaborative trials. Multimodahty treatment is based on risk stratification according to pretreatment stage, postoperative group, histology and site. Equivalent overall survival rates were reported in the last COG and SIOP trials, with worse event-free survival rates for bladder/prostate RMS in SIOP trials. The use of radiotherapy for local control was the main difference between COG and SIOP trials. Surgery is used to diagnose RMS and for local control after chemotherapy. One of the main tasks of treatment strategy is organ sparing result. Future combined studies are required to further treatment development of this childhood malignancy.