NEUROFIBROMATOSIS - CLINICAL POLYMORPHISM AND TREATMENT APPROACHES

Любченко Л. Н.; Филиппова М. Г.; L. N. Lubchenko; M. G. Filippova

NEUROFIBROMATOSIS - CLINICAL POLYMORPHISM AND TREATMENT APPROACHES

Authors: ¹, ¹, Lubchenko L.N.², Filippova M.G.²
Affiliations:
1. НИИ клинической онкологии РОНЦ им. Н.Н. Блохина РАМН
2. N.N. Blokhin Russian Cancer Research Center
Issue: Vol 3, No 4 (2011)
Pages: 29-36
Section: Articles
Published: 11.11.2011
URL: https://sarbon.abvpress.ru/jour/article/view/252
ID: 252

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Abstract

Neurofibromatosis consists of several genetically separate diseases - neurofibromatosis type I, neurofibromatosis type II, shwannomatosis and several clinical syndromes of unknown origin. This review discusses diagnostic criteria of neurofibromatosis type I, neurofibromatosis type II, shwannomatosis, novel data on molecular-genetic characteristics, phenotype-genotype correlations, mechanisms of pathogenesis and treatment approaches.