BASIC PRINCIPLES OF DYNAMIC CONTRAST-ENHANCED MAGNETIC RESONANCE IMAGING IN THE EVALUATION OF THE PREOPERATIVE CHEMOTHERAPY IN PATIENTS WITH BONE AND SOFT TISSUE SARCOMAS

Блудов А. Б.; Замогильная Я. А.; Неред А. С.; Кочергина Н. В.; Бохян Б. Ю.; Мачак Г. Н.; Феденко А. А.; Анурова О. А.; Заспа О. А.; A. B. Bludov; Y. A. Zamogilnaya; A. S. Nered; N. V. Kochergina; B. Y. Bokhyan; G. N. Machak; A. A. Fedenko; O. A. Anurova; O. A. Zaspa

BASIC PRINCIPLES OF DYNAMIC CONTRAST-ENHANCED MAGNETIC RESONANCE IMAGING IN THE EVALUATION OF THE PREOPERATIVE CHEMOTHERAPY IN PATIENTS WITH BONE AND SOFT TISSUE SARCOMAS

Authors: ¹, ¹, ¹, ¹^,2, ¹, ¹, ¹, ³, ¹, Bludov A.B.⁴, Zamogilnaya Y.A.⁴, Nered A.S.⁴, Kochergina N.V.⁴^,5, Bokhyan B.Y.⁴, Machak G.N.⁴, Fedenko A.A.⁴, Anurova O.A.⁶, Zaspa O.A.⁴
Affiliations:
1. Российский онкологический научный центр им. Н.Н. Блохина РАМН
2. РМАПО
3. ФГУ Московский научно-исследовательский онкологический институт им. П.А. Герцена Минздравсоцразвития России
4. N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences
5. Russian Medical Academy of Postgraduate Education
6. P.A Herzen Moscow Research Oncological Institute
Issue: Vol 3, No 4 (2011)
Pages: 41-50
Section: Articles
Published: 11.11.2011
URL: https://sarbon.abvpress.ru/jour/article/view/254
ID: 254

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Abstract

Magnetic resonance imaging (MRI) is widely used (method of choice) in therapy monitoring and in further dynamic control. MRI allows to evaluate changes in tumor size and structure during the treatment. However, as a result of heterogeneity in structure of bone and soft tissue sarcomas, these criteria don't allow to determine the effect of treatment properly in all clinical cases. This happens because this method doesn't reflect the most important criteria - the tumor vascularization and changes in vascularization during treatment. Thus, a new physiological method of MRI such as dynamic contrast-enhanced MRI (DCE MRI) is being developed. DCE MRI provides the better evaluation of response to preoperative treatment due to its ability in detection of highly vascularized zones in different sites of the tumor, which correlate with regions of viable tumor on pathologic examination. DCE MRI provides different types of analyses of tumor changes during therapy: quantitative, semi-qualitative and qualitative. The following review of literature demonstrates the basic principles of DCE MRI in assessing the efficacy of treatment in patients with bone and soft tissue sarcomas.