PHOTODYNAMIC THERAPY IN THE TREATMENT OF LOCALLY ADVANCED FORMS OF BASAL CELL SKIN CARCINOMA

Ярославцева-Исаева Е. В.; Каплан М. А.; Капинус В. Н.; Спиченкова И. С.; Шубина А. М.; Горанская Е. В.; Скугарева О. А.; Рагулин Ю. А.; E. V. Jaroslavceva-Isaeva; M. A. Kaplan; V. N. Kapinus; I. S. Spichenkova; A. M. Shubina; E. V. Goranskaja; O. A. Skugareva; Y. A. Ragulin

PHOTODYNAMIC THERAPY IN THE TREATMENT OF LOCALLY ADVANCED FORMS OF BASAL CELL SKIN CARCINOMA

Authors: ¹, ¹, ¹, ¹, ¹, ¹, ¹, ¹, Jaroslavceva-Isaeva E.V.², Kaplan M.A.², Kapinus V.N.², Spichenkova I.S.², Shubina A.M.², Goranskaja E.V.², Skugareva O.A.², Ragulin Y.A.²
Affiliations:
1. ФГБУ Медицинский радиологический научный центр Минздравсоцразвития России
2. Federal state institution of The Ministry of Health and Social development of The Russian Federation Medical Radiological Research Centre
Issue: Vol 3, No 4 (2011)
Pages: 56-61
Section: Articles
Published: 11.11.2011
URL: https://sarbon.abvpress.ru/jour/article/view/256
ID: 256

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Abstract

Aim of the study. To estimate efficiency of photodynamic therapy (PDT) with the photosensitizer «Photolon» in the treatment of patients with basal cell skin carcinoma by size of tumor more than 5 cm. Materials and methods. 32 patients with basal cell skin carcinoma by tumor size appropriate to T3-T4N0M0 were treated. PDT methods with external and interstitial laser irradiation and their combination with electrochemical lysis and radiotherapy were used. Results. The full regression of tumors T3N0M0 was observed in 84% cases, the partial regression in 16%, the relapses were revealed in 28,6% cases. The partial regression was marked in all patients with tumor size appropriate to T4N0M0. Absence of side reactions and complications allows to all patients with partial regression, extended growth of tumor and relapses to use repeated courses of PDT until achievement of full regression of tumor. Use of PDT methods with palliative aim to patients with basal cell skin carcinoma by tumor size appropriate to T4N0M0 allows tumor sizes to decrease, slow down tumor progression and improve life quality. Interstitial PDT and electrochemical lysis are increase efficiency of treatment. PDT in combination with radiotherapy allows dose of ionizing radiation (on 20-30%) and decrease risk of radiation complications. Conclusion. Photodynamic therapy is effective in the treatment of locally advanced basal cell skin carcinoma. PDT can be used alone and in combination with other methods.