TOWARDS INDIVIDUALIZED TREATMENT: PREDICTIVE FACTORS FOR CHEMOTHERAPY RELATED TOXIC EFFECT

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Abstract

Many drugs have been used for the treatment of cancer patients, but there is little information about how predictive factors can be used to aid treatment response and anticipate toxic effect related to anticancer treatment. There is a marked variability in drug handling between individual patients and this variability is based on genotyping individual patients. In this review we focus on genetic characteristics of xenobiotic-metabolizing enzymes. We also discuss the most valuable genetic predictive factors that relate to the toxic effects experienced by cancer patients treated with anticancer chemotherapy and the future prospects in this field of investigation.

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Российский онкологический научный центр им. Н.Н. Блохина РАМН

Author for correspondence.
Russian Federation

Российский онкологический научный центр им. Н.Н. Блохина РАМН

Russian Federation

Российский онкологический научный центр им. Н.Н. Блохина РАМН

Email: e_stepanova@nm.ru
Russian Federation

M. E. Abramov

N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences

Russian Federation

A. V. Shvarova

N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences

Russian Federation

E. V. Stepanova

N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences

Russian Federation

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Copyright (c) 2011 ., ., ., Abramov M.E., Shvarova A.V., Stepanova E.V.

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