Congenital cutaneous melanoma: molecular, genetic and clinical aspects

T. S. Belysheva; Белышева Т. С.; L. N. Lubchenko; Любченко Л. Н.; Y. V. Vishnevskaya; Вишневская Я. В.; T. V. Nasedkina; Наседкина Т. В.; M. A. Emelyanova; Емельянова М. А.; I. S. Abramov; Абрамов И. С.; K. V. Orlova; Орлова К. В.; I. A. Utyashev; Утяшев И. А.; M. B. Doroshenko; Дорошенко М. Б.; L. V. Demidov; Демидов Л. В.; M. D. Aliev; Алиев М. Д.

Congenital cutaneous melanoma: molecular, genetic and clinical aspects

Authors: Belysheva T.S.¹, Lubchenko L.N.¹, Vishnevskaya Y.V.¹, Nasedkina T.V.¹^,2, Emelyanova M.A.¹^,2, Abramov I.S.¹^,2, Orlova K.V.¹, Utyashev I.A.¹, Doroshenko M.B.¹, Demidov L.V.¹, Aliev M.D.¹
Affiliations:
1. FGBU «National Medical Research Center of Oncology named after N.N. Blokhin» of the Ministry of Health of Russia
2. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences
Issue: Vol 10, No 2 (2018)
Pages: 5-13
Section: EDITORIAL
Published: 16.05.2018
URL: https://sarbon.abvpress.ru/jour/article/view/26
ID: 26

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Abstract

Melanoma rarely affects children, it composes up to 0,9% of all pediatric malignancies. In children, as in adults, there is sporadic melanoma and family history forms of cutaneous melanoma. There is a number of known genes with mutations that can lead to the development of melanoma. In this article we focused on possible molecular genetic changes that occur in the cutaneous melanoma, with special attention to germinal mutations presenting literature data and our own experience.

Keywords

CDKN2A, BRAF, NRAS, cutaneus melanoma in children hereditary cutaneous melanoma, germinal mutations CDKN2A, BRAF, NRAS

About the authors

T. S. Belysheva

FGBU «National Medical Research Center of Oncology named after N.N. Blokhin» of the Ministry of Health of Russia

Author for correspondence.
Email: klinderma@bk.ru
Russian Federation

L. N. Lubchenko

FGBU «National Medical Research Center of Oncology named after N.N. Blokhin» of the Ministry of Health of Russia

Russian Federation

Y. V. Vishnevskaya

FGBU «National Medical Research Center of Oncology named after N.N. Blokhin» of the Ministry of Health of Russia

Russian Federation

T. V. Nasedkina

FGBU «National Medical Research Center of Oncology named after N.N. Blokhin» of the Ministry of Health of Russia; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences

Russian Federation

M. A. Emelyanova

FGBU «National Medical Research Center of Oncology named after N.N. Blokhin» of the Ministry of Health of Russia; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences

Russian Federation

I. S. Abramov

FGBU «National Medical Research Center of Oncology named after N.N. Blokhin» of the Ministry of Health of Russia; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences

Russian Federation

K. V. Orlova

FGBU «National Medical Research Center of Oncology named after N.N. Blokhin» of the Ministry of Health of Russia

Russian Federation

I. A. Utyashev

FGBU «National Medical Research Center of Oncology named after N.N. Blokhin» of the Ministry of Health of Russia

Russian Federation

M. B. Doroshenko

FGBU «National Medical Research Center of Oncology named after N.N. Blokhin» of the Ministry of Health of Russia

Russian Federation

L. V. Demidov

FGBU «National Medical Research Center of Oncology named after N.N. Blokhin» of the Ministry of Health of Russia

Russian Federation

M. D. Aliev

FGBU «National Medical Research Center of Oncology named after N.N. Blokhin» of the Ministry of Health of Russia

Russian Federation

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