Second primary cancers in patients with cutaneous melanoma in anamnesis

We have carried out the analysis of structure of recurrent malignant neoplasm by the constantly observed group of population after the radically cured MS. Materials and methods. From the year 1978 till 2011 100.000 people were under the constant clinical observation. The MS was diagnosed by 507 patients (243 men and 264 women). By all patients the diagnose was verified cytologically and/or histologically. The radical surgical cure of MS was done to 304 (60%) patients on the I stage; 106 (21%) on the II and 40 (8%) -on the III stage. By 56 (11%) people the stage was not established. In addition to the surgical cure 132 (26%) patients got chemotherapy and 7 (1,4%) immunotherapy. Later on all these patients were under the constant clinical observation. Results. Among 507 patients, who were treated for the MS, by 70 (14%) were other tumors subsequently exposed. This group includes 38(53%) men and 32(47%) women. By 70 patients were exposed 94 tumors, that chronologically appeared synchronically 81(86%) or metachronically 13 (14%). By 60 (86%) patients one tumor was diagnosed, by 6 (8%) two, by 3(4%) three, by one (1%) eleven tumors. The most often in a capacity of the second neoplasm was found basal cell carcinoma (BCC) 31 (33%) tumors. Most frequently BCC was diagnosed by men at the age of 50-59 years 14 (15%) tumors. Among the somatic oncopathology by the patients with MS in anamnesis the most often was found malignant neoplasm of the digestive tract 13 (14%) tumors, 5 (5%) of them falling to the share of stomach cancer. More seldom was diagnosed the neoplasm of prostate gland 12 (13%) neoplasias, breast cancer 8 (8,5%). Most often somatic neoplasm was exposed by men at the age of 70-79 years. By 37 (52%) patients the tumors were diagnosed after 6 or more years after the cured MS. Conclusions. After the radical treating of MS the long, maybe lifelong observations of such patients with oncologist and dermatologist are needed. A particular attention, obviously, should be given to the dermatologists’s examination of men at the age of 50-59 years and the inspection of digestive tract and prostate of men at the age of 70-79 years and the inspection of breast cancer of women at the age 70-79 years.

melanoma of skin, the constant clinical observation, secondary primary tumours