Experimental evaluation for efficacy and safety of combination with local ultrasound hyperthermia, iphosphamide and uroprotector

N. V. Andronova; Андронова Н. В.; I. D. Treshalin; Трещалин И. Д.; A. L. Nikolaev; Николаев А. Л.; B. Yu. Bokhyan; Бохян Б. Ю.; E. M. Treshalina; Трещалина Е. М.; M. D. Aliev; Переверзева Э. Р.; E. R. Pereverseva; Алиев М. Д.; A. V. Gopin; Гопин А. В.; V. E. Bozhevolnov; Божевальнов В. Е.; B. Ya. Kogan; Коган Б. Я.; G. N. Vorozhtcov; Ворожцов Г. Н.

Experimental evaluation for efficacy and safety of combination with local ultrasound hyperthermia, iphosphamide and uroprotector

Authors: Andronova N.V.¹, Treshalin I.D.¹, Nikolaev A.L.², Bokhyan B.Y.¹, Treshalina E.M.¹, Aliev M.D.¹, Pereverseva E.R.³, Gopin A.V.², Bozhevolnov V.E.², Kogan B.Y.⁴, Vorozhtcov G.N.⁴
Affiliations:
1. N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences
2. Moscow State University
3. Gause Institute of New Antibiotics, Russian Academy of Medical Sciences
4. Institute of Organic Materials and Dyes (FGUP GNC NOIPIK)
Issue: Vol 4, No 2 (2012)
Pages: 48-56
Section: EXPERIMENTAL ONCOLOGY
Published: 11.03.2012
URL: https://sarbon.abvpress.ru/jour/article/view/270
ID: 270

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Abstract

The aim of the study was to obtain experimental data on the specific antitumor activity of the thermochemotherapy (TCT), which combines local ultrasound hyperthermia and chemotherapy with iphosphamide and uroprotector natrium bicarbonate. Material and methods. The experiments were performed on mice with murine intramuscular transplanted hematogenic metastatic tumors Lewis lung carcinoma LLC and melanoma B16 with average volume of 0,8-1,7 cm³. Local ultrasound hyperthermia (US-HT) was performed on the original ultrasonic device USDT-m with local ultrasound of two frequencies (0,88 and 2,64 MHz) simultaneously with a maximum intensity of 2,5-3,0 W/cm² in the temperature 41,5⁰C. Ultrasonic treatment was carried out after systemic chemotherapy with ifosphamide (Ifo) and uroprotector natrium bacarbonate (NB). Results. It was shown that 1-2 courses of thermochemotherapy of the scheme NB+ 15 min + Ifo + 3 h + US-HT allows reducing the size of the tumor in 7-11 times with the same or less toxicity as demonstrates Ifo alone. Conclusion. The obtained results suggest a possibility to include the scheme of NB+Ifo+US-HT on USDT-m in clinical trial for preoperative treatment of patients with soft tissue sarcoma.

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thermo chemotherapy, local ultrasound hyperthermia, iphosphamide, natrium bicarbonate, mice, rats, transplanted tumors

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Experimental evaluation for efficacy and safety of combination with local ultrasound hyperthermia, iphosphamide and uroprotector

Full Text

Abstract

Keywords

About the authors

References

Supplementary files