Insulinlike growth factors 1 and 2, and insulinelike growth factor binding proteins 1 and 3 in bone tumors

N. E. Kushlinskii; Кушлинский Н. Е.; Yu. N. Soloviev; Соловьев Ю. Н.; Yu. S. Timofeev; Тимофеев Ю. С.; I. V. Babkina; Бабкина И. В.; O. I. Kostyleva; Костылева О. И.; I. V. Boulytcheva; Булычева И. В.; I. N. Kuznetsov; Кузнецов И. Н.; M. D. Aliev; Алиев М. Д.

Insulinlike growth factors 1 and 2, and insulinelike growth factor binding proteins 1 and 3 in bone tumors

Authors: Kushlinskii N.E.¹, Soloviev Y.N.¹, Timofeev Y.S.¹, Babkina I.V.¹, Kostyleva O.I.¹, Boulytcheva I.V.¹, Kuznetsov I.N.¹, Aliev M.D.¹
Affiliations:
1. N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences
Issue: Vol 4, No 3 (2012)
Pages: 53-57
Section: EXPERIMENTAL ONCOLOGY
Published: 11.06.2012
URL: https://sarbon.abvpress.ru/jour/article/view/282
ID: 282

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Abstract

Insulin-like growth factors 1 and 2 (IGF-1 and IGF-2) and insulin-like growth factor binding proteins IGFBP-1, IGFBP-3 were measured by ELISA techniques in blood serum of patients with 113 primary bone tumors. It was found a significant increase of IGF-1, 2 and IGFBP-1, 3 levels in bone tumors, compared to control group; significant increase of IGF-1, 2 levels in malignant bone tumors, compared to benign neoplasms of bones, and significant increase of IGFBP-3 levels in benign neoplasms compared to the malignant bone tumors and control group. Were found a significant differences of levels of these substances, depending on the histological type of cancer.

Keywords

insulin-like growth factors (IGF-1, IGF-2), insuline-like growth factor binding proteins (IGFBP-1, IGFBP-3), bone tumors

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Insulinlike growth factors 1 and 2, and insulinelike growth factor binding proteins 1 and 3 in bone tumors

Full Text

Abstract

Keywords

About the authors

References

Supplementary files