ISOLATED CHEMOTHERAPEUTIC PERFUSION IN THE TREATMENT OF LOCALLY ADVANCED PELVIC TUMORS

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Abstract

A method of isolated pelvic perfusion creates a high concentration of chemotherapy in the pelvic cavity and usually used in locally advanced soft tissue sarcomas, recurrent locally advanced colorectal cancer or gynecological cancer pathology, often after a previous combined treatment including chemotherapy and radiation therapy. pelvic perfusion can be used with different schemes of chemotherapy, but the inclusion of melphalan, especially in combination with tumor necrosis factor, provides a level of objective responses, comparable with the results of isolated limb perfusion. pelvic perfusion technique improves with time, applies compression tools, imposes above projections bifurcation iliac vessels to create maximum isolation of the region, used with improved vascular access, and selected most effective combination of chemotherapy. Currently, there are few randomized studies to identify opportunities for the pelvic perfusion for sarcomas and carcinomas of the pelvis.

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T. K. Kharatishvili

N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Science

Author for correspondence.
Russian Federation

D. V. Martynkov

N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Science

Email: generaloncology@rambler.ru
Russian Federation

B. Yu. Bokhyan

N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Science

Russian Federation

A. A. Fedenko

N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Science

Russian Federation

A. P. Nicolaev

N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Science

Russian Federation

M. D. Aliev

N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Science

Russian Federation

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Copyright (c) 2012 Kharatishvili T.K., Martynkov D.V., Bokhyan B.Y., Fedenko A.A., Nicolaev A.P., Aliev M.D.

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