ANALYSIS OF THE CYTOTOXIC ACTIVITY OF BOTANICAL EXTRACTS IN MELANOMA CELL LINES IN VITRO

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Abstract

Background. We analyzed cytotoxic properties of different aqueous-alcoholic extracts from plants on 4 metastatic skin melanoma cell lines in vitro. Methods. The cytotoxic activity of 18 aqueous-alcoholic extracts was assessed on 5 metastatic melanoma cell lines (mel Kor, mel P, mel Il, mel Cher and Melur) by a MTT test. results. 9 (50%) plant extracts demonstrated no significant cytotoxic effect at the highest tested concentration (0,3% alcohol). Only extracts from Eucommia ulmoides L. and Eleutherococcus L. had noteworthy cytotoxic effects in four and more cell lines tested. Conclusion. The cytotoxic activities of botanical extracts and their fractions on metastatic melanoma cell lines require further closer investigations.

About the authors

E. Sh. Solomko

N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Science

Author for correspondence.
Russian Federation

E. R. Polosuhina

N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Science

Russian Federation

A. M. Rabinovich

GSI VILAR RASHN

Russian Federation

A. V. Kiselev

N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Science

Russian Federation

E. V. Stepanova

N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Science

Email: e_stepanova@nm.ru
Russian Federation

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Copyright (c) 2012 Solomko E.S., Polosuhina E.R., Rabinovich A.M., Kiselev A.V., Stepanova E.V.

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