ANALYSIS OF GSTP1 AND ABCB1 SINGLE-NUCLEOTIDE POLYMORPHISM IN CHILDREN WITH SOFT TISSUE AND BONE SARCOMAS

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Abstract

Background. We analyzed the relationship between GSTP1 and ABCB1 single-nucleotide polymorphism and chemotherapy efficacy and toxicity in children with soft tissue and bone sarcomas. Methods. The study 58 children with high risks soft tissue and bone sarcomas included to the study. Genotyping of GSTP1 (105)Ile/(105)Val (rs1695) and ABCB1 3435C>T (rs1045642) were performed by genomic DNA extracted from blood mononuclear cells. Results. GSTP1 (105)Ile/(105)Val and ABCB1 3435C>T genotypes had no association with frequency or grade hematological toxicity. Patients with GSTP1 (105)Ile/(105)Val GG genotype had a greater risk of the disease recurrence and shorter diseasefree survival in comparison with AA genotype patients. Conclusion. Assessment of GSTP1 genotype may be important in selecting children suitable for chemotherapy.

About the authors

Yu. A. Khochenkova

FSBI «N.N. Blokhin Russian Cancer Research Center» RAMS

Author for correspondence.
Russian Federation

R. N. Geidarov

FSBI science Engelhardt Institute of Molecular Biology Russian Academy of Sciences

Russian Federation

E. E. Fesenko

Institute of cell Biophysics RAS

Russian Federation

A. V. Shvarova

FSBI «N.N. Blokhin Russian Cancer Research Center» RAMS

Russian Federation

N. M. Ivanova

FSBI «N.N. Blokhin Russian Cancer Research Center» RAMS

Russian Federation

M. E. Abramov

FSBI «N.N. Blokhin Russian Cancer Research Center» RAMS

Russian Federation

E. V. Stepanova

FSBI «N.N. Blokhin Russian Cancer Research Center» RAMS

Email: e_stepanova@nm.ru
Russian Federation

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Copyright (c) 2012 Khochenkova Y.A., Geidarov R.N., Fesenko E.E., Shvarova A.V., Ivanova N.M., Abramov M.E., Stepanova E.V.

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