Isolated regional limb perfusion in the treatment of patients with melanoma of the skin

It was performed an analysis of published data on possible methods of isolated regional perfusion (IRP) in the treatment of locally advanced extremity melanoma. It is shown that the method is becoming more common as superior to other methods in the treatment of tumors of this embodiment. It was found that when using IRP average five-year survival without signs of the disease is 39%, while in patients underwent IRP was unresectable tumor with a poor prognosis. In regard to safety performance it demonstrated that IRP is rarely accompanied by severe manifestations of local or systemic toxicity. These data confirm the safety and the possibility of using IRP method in a clinical setting. The study of patients after IRP quality of life showed an increase in its level after treatment by this method. There are reports on the efficacy of the method in combination with surgical treatment of the tumor. However, to date there is no evidence that adjuvant IRP extends the life of patients with melanoma, indicating a need for further research possibilities of this method.