Prevalence and Clinical Significance of Merkel cell polyomavirus in Merkel cell carcinoma

K. V. Orlova; Орлова К. В.; V. V. Delektorskaya; Делекторская В. В.; M. G. Yakubovskaya; Якубовская М. Г.; Y. V. Vishnevskaya; Вишневская Я. В.; T. T. Kondratieva; Кондратьева Т. Т.; N. F. Orel; Орел Н. Ф.; L. V. Demidov; Демидов Л. В.

Prevalence and Clinical Significance of Merkel cell polyomavirus in Merkel cell carcinoma

Authors: Orlova K.V.¹, Delektorskaya V.V.¹, Yakubovskaya M.G.¹, Vishnevskaya Y.V.¹, Kondratieva T.T.¹, Orel N.F.¹, Demidov L.V.¹
Affiliations:
1. N.N Blokhin Russian Cancer Research Center
Issue: Vol 6, No 3-4 (2014)
Pages: 58-62
Section: TUMORS OF THE SKIN
Published: 25.11.2014
URL: https://sarbon.abvpress.ru/jour/article/view/455
ID: 455

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Abstract

Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine skin cancer that is often associated with Merkel cell polyomavirus (MCPyV) infection. MCPyV prevalence and its relationship with clinical features and prognosis in MCC remain unclear. The aim of the study was to investigate the frequency and pattern of the MCPyV expression in primary and metastatic tumors from patients with MCC and evaluate the role of MCPyV in prognosis of patients with MCC in russia.