Value of intra-arterial chemotherapy in surgical treatment of non ephithelial malignant tumors of maxilla, nasal and paranasal sinuses

Background. To study a role of long intra arterial chemotherapy in surgical treatment of patients with non-epithelial malignant tumors of the maxilla, cavity of a nose and the paranasal sinuses.
Methods. During the period 2000–2008 and in 2014 38 patients with non-epithelial malignant tumors of the maxilla and the paranasal sinuses were treated. Patients depending on a method of treatment at the first stage were divided into 4 groups:
1) long intra-arterial chemotherapy with local uhf-hyperthermia and radiation therapy (10 patients); 2) long intra-arterial chemotherapy and radiation therapy (13 patients); 3) systemic chemotherapy and radiation therapy (5 patients); 4) radiation therapy with a subsequent operation (9 patients).
Results. Surgical treatment at the second stage of complex treatment, was carried out in 31 (83,7%) out of 37 patients. Partial resection of the мaxilla, removal of the struck anatomical structure was done in 2 (6,4%) patients. maxilla resection was done in 14 (45,1%) patients. Extended maxilla resection was performed in 13 (41,9%) pts. maxilla resection with orbital exenteration was made in 1 (3,2%) case. ethmoid sinus resection was performed in 1 (3,2%) patients.
Conclusion. Thus, neoadjyuvantny intraarterial chemotherapy in the 1^st and 2^nd groups of patients, allowed to reduce the volume of surgeries than at sick 3^rd and 4^th groups, which received traditional methods of treatment.