Limb-sparing treatment results for spontaneous canine osteosarcoma patients with allogenic bone transplantation

Background. Canine osteosarcoma is a most common bone tumor in dogs, usually involving long tubular bones lesion. Limb-sparing treatment method allows to save extremity functionality and sufficiently improve quality of life in comparison with amputation. Objective. Analysis of survival rates and local results after limb-sparing treatment of canine osteosarcoma using bio-implantation (de-immunized allogenic bone populated with recipient stromal mesenchymal cell preparation). Materials and methods. Group of 25 dogs underwent a combined treatment including cisplatinum chemotherapy (60-70 mg/m² i/v infusion at 14-21 day intervals, up to 4 cycles) and wide segmental resection of the affected bone with a bio-implant defect replacement. Overall survival, progression-free survival and local recurrence frequency in the group were analyzed. Results. The median overall survival was 321 day, and median progression-free was 222 days. 4 cases (16.6%) of local relapse were recorded, 2 of which were confirmed by radiography and histological examination, and 2 other by radiography only. Conclusion. Efficiency of the canine appendicular osteosarcoma combined limb-sparing treatment is comparable with amputation practice results (according to scientific literature) while foregoing method is preferable due to higher life quality of patients.

bioimplantation, bone, limb-sparing surgery, osteosarcoma, dog