Angiosarcomas

A. A. Fedenko; Феденко Александр Александрович; A. A. Konev; Конев А. А.; O. A. Anurova; Анурова О. А.; V. A. Gorbunova; Горбунова В. А.; V. A. Sobolevsky; Соболевский В. А.; B. U. Bohyan; Бохян Б. Ю.; L. N. Lyubchenko; Любченко Л. Н.; T. K. Kharatishvili; Харатишвили Т. К.

Angiosarcomas

Authors: Fedenko A.A.¹, Konev A.A.¹, Anurova O.A.¹, Gorbunova V.A.¹, Sobolevsky V.A.¹, Bohyan B.U.¹, Lyubchenko L.N.¹, Kharatishvili T.K.¹
Affiliations:
1. FGBU N.N. Blokhin Russian Cancer Research Center
Issue: Vol 5, No 1 (2013)
Pages: 24-41
Section: SOFT TISSUE SARCOMAS
Published: 03.02.2013
URL: https://sarbon.abvpress.ru/jour/article/view/496
ID: 496

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Abstract

Angiosarcomas are one of the rarest forms of soft tissue neoplasms. They make up a small fraction of all vascular tumors, and less than 1% of all sarcomas. Prognosis and treatment depends on the location of the primary tumor. Angiosarcomas can be divided into several clinical subgroups: angiosarcomasnot associated with lymphedema; angiosarcomas associated with lymphedema (so-called lymphangiosarcomas); angiosarcomas of the breast; angiosarcomas of deep soft tissue and radiation-induced angiosarcomas. The main treatment is radical surgery (with histological examination of surgical margins). Postoperative radiotherapy improves overall survival. There are still no recommended standardsof chemotherapy in the treatment of angiosarcomas. Taxane-based chemotherapy is possible. We recommend chemotherapy regime GemTax as 1st-line treatment, which has shown to be effective. The overall efficiency was 38%. Control of tumor growth was equal to 93%. In case of affection of the scalp weekly administration of paclitaxel is possible. In case of organ angiosarcomas a combination of ifosfamide with doxorubicin can be also used.

Keywords

ангиосаркома, лимфостаз, радиоиндуцированная ангиосаркома, химиотерапия, angiosarcomas, lymphedema, radiation-induced angiosarcoma, chemotherapy

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Angiosarcomas

Full Text

Abstract

Keywords

About the authors

References

Supplementary files