Experimental approaches of nanoparticles using in the diagnostics and therapy of soft tissue tumors

H. M. Treshalina; Трещалина Е. М.; N. V. Andronova; Андронова Н. В.; A. L. Nikolaev; Николаев А. Л.; A. V. Gopin; Гопин А. В.; V. E. Bozhevolnov; Божевольнов В. Е.; B. Yu. Bokhyan; Бохян Б. Ю.; G. A. Meerovoch; Меерович Г. А.; V. B. Loschenov; Лощенов В. Б.; S. Sh. Karsieva; Каршиева С. Ш.; B. I. Dolgushin; Долгушин Б. И.

Experimental approaches of nanoparticles using in the diagnostics and therapy of soft tissue tumors

Authors: Treshalina H.M.¹, Andronova N.V.¹, Nikolaev A.L.¹, Gopin A.V.¹, Bozhevolnov V.E.¹, Bokhyan B.Y.¹, Meerovoch G.A.¹, Loschenov V.B.¹, Karsieva S.S.¹, Dolgushin B.I.¹
Affiliations:
1. FGBu N.N. Blokhin Russian Cancer Research Center
Issue: Vol 5, No 1 (2013)
Pages: 60-66
Section: EXPERIMENTAL ONCOLOGY
Published: 03.02.2013
URL: https://sarbon.abvpress.ru/jour/article/view/500
ID: 500

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Abstract

The purpose of evaluation was the analysis of experimental data about the using possibilities of the different nanostructures together with local ultrasound, magnetic or laser irradiation for diagnostics and therapy of the malignant tumors. On the developed solid intramuscular tumor models with different histological genesis was shown, that solid-phase inclusions (nanoclasters) in tumor together with local ultrasound leads to the significant increasing of therapeutically efficacy. The experimental evaluation was confirmed that this phenomenon realizes through increase evolution of heat and reducing of cavitations’ threshold and impact on mechanical strength of biological membranes associated with the presence in zone the irradiation of solid inclusions. Discussed the possibility of transport of anticancer drugs using nanoparticles in combination with local ultrasound exposure and improvement of visualization of the lesion by modifying tumor by the solid-phase inclusions. It was shown that improvement of laser diagnostics methods involved with the ferromagnetic nano-contrasters. The possibility to improving of electromagnetic or laser hyperthermia through composed nanostructures on the ground of magnetic nanoparticles with high sensitive to operating influence thin graphite covering was discussed. Obtained effects and the conclusions based on some assumptions suggest that the application of nanotechnology will improve the efficiency of diagnosis and treatment of soft tissue tumors in patients.

Keywords

наноструктуры, ультразвук, лазерное и магнитное излучения, опухолевые модели, диагностика, терапия, nanostructures, ultrasound, laser or magnetic irradiation, tumor model, diagnostics, therapy

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Experimental approaches of nanoparticles using in the diagnostics and therapy of soft tissue tumors

Full Text

Abstract

Keywords

About the authors

References

Supplementary files