The sterile deimmunized matrix for the replacement of extended defects in bone

N. Yu. Anisimova; Анисимова Наталья Юрьевна; A. N. Kopylov; Копылов А. Н.; E. A. Kornyushenkov; Корнюшенков Е. А.; D. E. Mitrushkin; Митрушкин Д. Е.; A. V. Maximkin; Максимкин А. В.; E. A. Sushenzov; Сушенцов Е. А.; M. V. Kiselevsky; Киселевский М. В.

The sterile deimmunized matrix for the replacement of extended defects in bone

Authors: Anisimova N.Y.¹, Kopylov A.N.¹, Kornyushenkov E.A.¹, Mitrushkin D.E.¹, Maximkin A.V.², Sushenzov E.A.¹, Kiselevsky M.V.¹
Affiliations:
1. FGBU N.N. Blokhin Russian Cancer Research Center
2. National university of science and Technology «MISIS»
Issue: Vol 5, No 2 (2013)
Pages: 49-54
Section: EXPERIMENTAL ONCOLOGY
Published: 03.05.2013
URL: https://sarbon.abvpress.ru/jour/article/view/514
ID: 514

Cite item

Full Text

Abstract
About the authors
References
Supplementary files
Statistics

Abstract

On the base of N.N. Blokhin Russian Cancer Research Center of RAMs had been designed the method of acquiring sterile deimmunized matrix from donor bone. This matrix can be used as a base for bioimplants for replacing bone defects. The aim of the research was the estimation of influence of the chemical treatment to the bone mechanical properties and the suppression of acute implant rejection. It was proved that the method provides sterilization and decreases immunogenicity of the matrix (absence of any degradation signs and absence of rejection reaction spreading during syngenic heterotopic transplantation in mice). After applying this method, we do not observe any signs of decreasing of mechanical properties (yield stress, Young's modulus, ultimate stress) in comparison with intact bone.

Keywords

матрикс, кость, деиммунизация, прочность, стерильность, matrix, bone, deimmunization, strength, sterility

References

Supplementary files

Supplementary Files

Action

1. JATS XML

Download

Username
Password
Remember me

Forgot password?	Register

Username
Password
Remember me

Forgot password?	Register

The sterile deimmunized matrix for the replacement of extended defects in bone

Full Text

Abstract

Keywords

About the authors

N. Yu. Anisimova

A. N. Kopylov

E. A. Kornyushenkov

D. E. Mitrushkin

A. V. Maximkin

E. A. Sushenzov

M. V. Kiselevsky

References

Supplementary files