Email this article Overall and relapse-free survival of dogs with appendicular osteosarcoma after limb-sparing bio-implantation treatment
- Authors: Kornyushenkov E.A.1,2, Mitrushkin D.E.1,2, Garanin D.V.2, Kuznetsova A.L.1,2, Fateeva E.A.1,2, Kiselevsky M.V.3, Anisimova N.Y.1, Zakharov E.V.1,2, Shimshirt A.A.1,2
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Affiliations:
- Clinic of Experimental Therapy of the N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russia
- Veterinary Сlinic “Biocontrol”
- Cell Immunity Laboratory of the N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russia
- Issue: Vol 15, No 4 (2023)
- Pages: 33-39
- Section: BONE SARCOMAS
- Published: 12.12.2023
- URL: https://sarbon.abvpress.ru/jour/article/view/630
- DOI: https://doi.org/10.17650/2219-4614-2023-15-4-33-39
- ID: 630
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Abstract
Introduction. Canine osteosarcoma is a most common bone tumor in dogs, usually involving long tubular bones lesion. Limb-sparing treatment method allows to save extremity functionality and sufficiently improve quality of life in comparison with amputation.
Aim. To analyze the survival rates and local results after limb-sparing treatment of canine osteosarcoma using bio-implantation – de-immunized allogenic bone populated with recipient stromal mesenchymal cell preparation.
Materials and methods. Group of 25 dogs underwent a combined treatment including cisplatinum chemotherapy (60–70 mg/m2 intravenously infusion at 14–21 day intervals, up to 4 cycles) and wide segmental resection of the affected bone with a bioimplant defect replacement. Overall survival, progression-free survival and local recurrence frequency in the group were analyzed.
Results. Overall survival median was 321 day, and progression-free median was 222 days. 4 (16,6 %) cases of local relapse were recorded, 2 of which were confirmed by radiography and histological examination, and 2 other by radiography only.
Conclusion. Efficiency of the canine appendicular osteosarcoma combined limb-sparing treatment is comparable with amputation practice results (according to scientific literature) while foregoing method is preferable due to higher life quality of patients.
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About the authors
E. A. Kornyushenkov
Clinic of Experimental Therapy of the N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russia; Veterinary Сlinic “Biocontrol”
Author for correspondence.
Email: evg-kornyushenkov@yandex.ru
Evgeny Aleksandrovich Kornyushenkov
24 Kashirskoye Shosse, Moscow 115522
Bld. 10, 24 Kashirskoye Shosse, Moscow 115522
Russian FederationD. E. Mitrushkin
Clinic of Experimental Therapy of the N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russia; Veterinary Сlinic “Biocontrol”
ORCID iD: 0000-0003-3778-303X
24 Kashirskoye Shosse, Moscow 115522
Bld. 10, 24 Kashirskoye Shosse, Moscow 115522
Russian FederationD. V. Garanin
Veterinary Сlinic “Biocontrol”
ORCID iD: 0009-0004-1897-8389
Bld. 10, 24 Kashirskoye Shosse, Moscow 115522
Russian FederationA. L. Kuznetsova
Clinic of Experimental Therapy of the N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russia; Veterinary Сlinic “Biocontrol”
ORCID iD: 0000-0003-0180-8434
24 Kashirskoye Shosse, Moscow 115522
Bld. 10, 24 Kashirskoye Shosse, Moscow 115522
Russian FederationE. A. Fateeva
Clinic of Experimental Therapy of the N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russia; Veterinary Сlinic “Biocontrol”
ORCID iD: 0009-0000-5414-2571
24 Kashirskoye Shosse, Moscow 115522
Bld. 10, 24 Kashirskoye Shosse, Moscow 115522
Russian FederationM. V. Kiselevsky
Cell Immunity Laboratory of the N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russia
ORCID iD: 0000-0002-0132-167X
24 Kashirskoye Shosse, Moscow 115522
Russian FederationN. Yu. Anisimova
Clinic of Experimental Therapy of the N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russia
ORCID iD: 0000-0002-4370-6578
24 Kashirskoye Shosse, Moscow 115522
Russian FederationE. V. Zakharov
Clinic of Experimental Therapy of the N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russia; Veterinary Сlinic “Biocontrol”
ORCID iD: 0009-0007-7852-783X
24 Kashirskoye Shosse, Moscow 115522
Bld. 10, 24 Kashirskoye Shosse, Moscow 115522
Russian FederationA. A. Shimshirt
Clinic of Experimental Therapy of the N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russia; Veterinary Сlinic “Biocontrol”
ORCID iD: 0000-0001-6913-3248
24 Kashirskoye Shosse, Moscow 115522
Bld. 10, 24 Kashirskoye Shosse, Moscow 115522
Russian FederationReferences
- Mitchell K.E., Boston S.E., Kung M. et al. Outcomes of limb-sparing surgery using two generations of metal endoprosthesis in 45 dogs with distal radial osteosarcoma. A Veterinary Society of Surgical Oncology retrospective study. Vet Surg 2016;45(1):36–43. doi: 10.1111/vsu.12423
- MacDonald T.L., Schiller T.D. Limb-sparing surgery using tantalum metal endoprosthesis in a dog with osteosarcoma of the distal radius. Can Vet J 2010;51(5):497–500.
- Jehn C., Farese J., Lewis D. et al. Current treatment options for dogs with appendicular osteosarcoma. Vet Med 2005;100:295–305.
- Gassel A., Bilbrey S. Limb-sparing surgery for appendicular osteosarcoma in dogs. Vet Med 2003;8:119–24.
- Morello E., Buracco P., Martano M. et al. Bone allografts and adjuvant cisplatin for the treatment of canine appendicular osteosarcoma in 18 dogs. J Small Anim Pract 2001;42(2):61–6. doi: 10.1111/j.1748-5827.2001.tb01993.x
- Lascelles B.D., Dernell W.S., Correa M.T. et al. Improved survival associated with postoperative wound infection in dogs treated with limbsalvage surgery for osteosarcoma. Ann Surg Oncol 2005;12(12):1073– 83. doi: 10.1245/ASO.2005.01.011
- Mitin V.N., Soloviev Yu.N., Yagnikov S.A. and others. Postoperative relapses of osteogenic sarcoma in dogs with bone distraction by the Elizarov method. Arhiv Patologii = Archive of Pathology 1998;60(4). Available at: https://www.biocontrol.ru/specialistam/onkologiya/posleoperacionnye-recidivy-osteogennoj-sarkomy-usobak-pri-distrakcii-kosti-po-metodu-ilizarova.html.
- Kornyushenkov E.A., Golub L.V., Anisimova N.Yu. et al. New ways to solve the problem of defect replacement during extensive resection in animals with bone tumors. Rossijskij veterinarnyj zhurnal. Melkie domashnie i dikie zhivotnye = Russian Veterinary Journal. Small domestic and wild animals 2013;3:12–6. (In Russ.).
- Liptak J.M., Dernell W.S., Ehrhart N. et al. Cortical allograft and endoprosthesis for limb-sparing surgery in dogs with distal radial osteosarcoma: a prospective clinical comparison of two different limbsparing techniques. Vet Surg 2006;35(6):518–33. doi: 10.1111/j.1532-950X.2006.00185.x
- Withrow S.J., Liptak J.M., Straw R.C. et al. Biodegradable cisplatin polymer in limb-sparing surgery for canine osteosarcoma. Ann Surg Oncol 2004;11(7):705–13. doi: 10.1245/ASO.2004.10.008
- Anisimova N.Yu., Kopylov A.N., Kornyushenkov E.A. et al.The sterile deimmunized matrix for the replacement of extended defects in bone. Sarkomy kostei miagkikh tkanei i opukholi kozhi = Bone and Soft Tissue Sarcomas, Tumors of the Skin 2013;(2):49–54. (In Russ.).
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