Modern views on the perfusion chemotherapy possibilities in the malignant tumors treatment

Currently, the complex treatment of malignant neoplasms of various localizations is used perfusion technology more commonly. We performed the analysis of literature on the use of perfusion chemotherapy in the treatment of tumors. The basic physical principles of delivering a chemotherapy drug (CP) to tumor tissues were considered, and it was noted that to ensure the effectiveness of this process, it is necessary to overcome high vascular resistance, high pressure of interstitial fluid and fibrous stroma around the tumor. It presented the factors contributing to the increase in CP in interstitial tissue, including ischemic vasodilation, low viscosity of injected fluids and bolus drug delivery. It is noted that when applying the method of intraarterial perfusion, the pressure of fluid flow increases, this causes the «leaching» of the intravascular protein in the interstitium, CP does not undergo reabsorption in the venous section, and the tumor is completely retained by the tissue. It is indicated that further study of the physicochemical principles of the application of this method will contribute to a significant increase in the survival rate of cancer patients in whom conservative treatment methods prove ineffective.

chemotherapy, malignant tumors, intraarterial perfusion, fluid mass transfer (MFT), oncotic pressure