Breast sarcoma. Choice of treatment tactics. The forecast factors

Breast sarcomas are rare heterogeneous tumors in breast and the optimal treatment for them is still under discussion. Patients and methods. We retrospectively reviewed 51 patients with BS between 1999 and 2017 in N.N. Blochin Russian Cancer Research Center Ministry of Health of the Russian Federation. Results. Five-year recurrence-free survival and OS rate were 37.5% and 56.2%, respectively. With median follow-up of 86.4 months, 43.14% patients (22/51) were found with local recurrence and metastasis. 93.33% of all distant metastases and 80% of all relapses were found in patients with stage III disease and G3 with only surgical treatment. Also, 84.61% of all separated metastases were detected in patients in the group with more malignant tumor subtypes (malignant fibrous histiocytoma, spindle cell sarcoma) with surgical treatment only. Conclusion. The combined approach is necessary in the treatment of high-grade sarcomas, taking into account the morphological and immunohistochemical parameters of the tumor. Disease stage and local recurrence were indicated as unfavorable prognostic factors. Surgery remains crucial treatment for breast sarcomas. Mastectomy is not routinely necessary if clear margin could be achieved by local excision.

breast sarcoma, surgical treatment