Email this article Synovial sarcoma: current view of pathogenesis and therapeutic approaches
- Authors: Senchenko M.A.1,2, Tararykova A.A.1, Kozlov N.A.1, Fetisov T.I.3, Kirsanov K.I.3, Rogozhin D.V.1,4
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Affiliations:
- N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
- Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Health of Russia
- RUDN Universtiy
- Pirogov Russian National Research Medical University, Ministry of Health of Russia
- Issue: Vol 17, No 3 (2025)
- Pages: 26-37
- Section: REVIEWS
- Published: 14.10.2025
- URL: https://sarbon.abvpress.ru/jour/article/view/762
- DOI: https://doi.org/10.17650/2219-4614-2025-17-3-26-37
- ID: 762
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Abstract
Synovial sarcoma is characterized by a typical transcript SS18::SSX. However, despite a common pathogenesis and similar therapeutic approaches, opposite responses to therapy are sometimes observed. Supposedly, this can be associated with additional and alternative pathways of genetic and epigenetic regulation.
In this review, the problems of synovial sarcoma diagnosis, pathogenesis and new therapy methods, including targeting epigenetics, are discussed.
About the authors
M. A. Senchenko
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia; Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Health of Russia
ORCID iD: 0000-0002-9921-5620
24 Kashirskoe Shosse, Moscow 115522
Russian FederationA. A. Tararykova
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
ORCID iD: 0000-0002-5548-3295
24 Kashirskoe Shosse, Moscow 115522
Russian FederationN. A. Kozlov
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
ORCID iD: 0000-0003-3852-3969
24 Kashirskoe Shosse, Moscow 115522
Russian FederationT. I. Fetisov
RUDN Universtiy
ORCID iD: 0000-0002-5082-9883
6 Miklukho-Maklaya St., Moscow 117198
Russian FederationK. I. Kirsanov
RUDN Universtiy
ORCID iD: 0000-0002-8599-6833
6 Miklukho-Maklaya St., Moscow 117198
Russian FederationD. V. Rogozhin
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia; Pirogov Russian National Research Medical University, Ministry of Health of Russia
Author for correspondence.
Email: pathol.777@mail.ru
ORCID iD: 0000-0003-0777-9152
Dmitry Viktorovich Rogozhin
24 Kashirskoe Shosse, Moscow 115522
1 Ostrovityanova St., 117513 Moscow
Russian FederationReferences
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