Bone and soft tissue sarcomas, tumors of the skinBone and soft tissue sarcomas, tumors of the skinСаркомы костей, мягких тканей и опухоли кожи2219-46142782-3687Publishing House ABV Press1010.17650/2070-9781-2020-12-4-11-21EDITORIALОТ РЕДАКЦИИManagement of giant cell tumor in the denosumab era. Literature reviewСовременный взгляд на лечение гигантоклеточной опухоли кости в эру деносумаба. Обзор литературыhttps://orcid.org/0000-0002-5548-3295TararykovaA. A.ТарарыковаА. А.
Russian Federation

24 Kashirskoe Shosse, Moscow 115478

115478 Москва, Каширское шоссе, 24

anastasiatararykova@gmail.comhttps://orcid.org/0000-0003-4927-5585FedenkoA. A.ФеденкоА. А.
Russian Federation

 3 2nd Botkinskiy Proezd, 125284 Moscow

125284 Москва, 2-й Боткинский проезд, 3

https://orcid.org/0000-0002-1241-3019MusaevE. R.МусаевЭ. Р.
Russian Federation

24 Kashirskoe Shosse, Moscow 115478

115478 Москва, Каширское шоссе, 24

N.N. Blokhin National Medical Research Center of Oncology оf the Ministry of Health of the Russian FederationФГБУ «Национальный медицинский исследовательский центр онкологии им. Н. Н. Блохина» Минздрава РоссииNational Medical Research Radiological Center of the Ministry of Health of the Russian FederationФГБУ «Национальный медицинский исследовательский центр радиологии» Минздрава России0611202012411210604202106042021Copyright ©; 2020, Tararykova A.A., Fedenko A.A., Musaev E.R.Copyright ©; 2020, Тарарыкова А.А., Феденко А.А., Мусаев Э.Р.2020Tararykova A.A., Fedenko A.A., Musaev E.R.Тарарыкова А.А., Феденко А.А., Мусаев Э.Р.https://creativecommons.org/licenses/by/4.0https://sarbon.abvpress.ru/jour/article/view/10

The article represents a literature review of the giant cell tumor management based on the RANKL overexpression and according this use of the denosumab.Weconsidered the pathogenesis of giant cell tumor based on the process of osteoclastogenesis (RANK/RANKL) discovered in the 1990s and a new H3F3A driver mutation. The history, experience and results of the denosumab treatment, as well as the issues of evaluation and interpretation of the treatment response are represented.

В статье представлен обзор мировой литературы на тему лечения гигантоклеточной опухоли кости с учетом сверх-экспрессии RANKL и основанного на этом применения деносумаба. Рассмотрены аспекты патогенеза гигантоклеточной опухоли на основе открытого в 1990-х годах процесса остеокластогенеза (RANK/RANKL) и новой драйвер-мутации H3F3A.  Представлены  история,  опыт  и  результаты  применения  деносумаба,  а  также  проблемы  оценки и интерпретации эффекта лечения.

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