Bone and soft tissue sarcomas, tumors of the skinBone and soft tissue sarcomas, tumors of the skinСаркомы костей, мягких тканей и опухоли кожи2219-46142782-3687Publishing House ABV Press11010.17650/2070-9781-2021-13-1-24-31BONE SARCOMASСАРКОМЫ КОСТЕЙMolecular, biological and diagnostic features of Ewing sarcoma and undifferentiated small round cell sarcomas of bone and soft tissueМолекулярно-биологические и диагностические особенности саркомы Юинга и группы недифференцированных мелкокруглоклеточных опухолей костей и мягких тканейhttps://orcid.org/0000-0002-1661-4205SinichenkovaK. Y.СиниченковаК. Ю.
Russian Federation

1 Samory Mashela St., Moscow 117198

117198 Москва, ул. Саморы Машела, 1

ksinichenkova@gmail.comhttps://orcid.org/0000-0002-9375-7517RoschinV. Y.РощинВ. Ю.
Russian Federation

1 Samory Mashela St., Moscow 117198

117198 Москва, ул. Саморы Машела, 1

https://orcid.org/0000-0003-1308-8622DruyA. E.ДруйА. Е.
Russian Federation

1 Samory Mashela St., Moscow 117198

117198 Москва, ул. Саморы Машела, 1

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology, Ministry of Healh of RussiaФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава России0306202113124310206202102062021Copyright ©; 2021, Sinichenkova K.Y., Roschin V.Y., Druy A.E.Copyright ©; 2021, Синиченкова К.Ю., Рощин В.Ю., Друй А.Е.2021Sinichenkova K.Y., Roschin V.Y., Druy A.E.Синиченкова К.Ю., Рощин В.Ю., Друй А.Е.https://creativecommons.org/licenses/by/4.0https://sarbon.abvpress.ru/jour/article/view/110

Ewing’s sarcoma is a highly malignant small round cell tumor with a unique rearrangement of the EWSR1 (FUS) gene with partners genes of ETS family. Tumors with Ewing's sarcoma morphological features lacking without specific EWSR1 rear-rangement called undifferentiated small round cell sarcomas of bone and soft tissue. This group includes: sarcomas with СIC gene rearrangement, sarcomas with BCOR gene rearrangement and sarcomas with EWSR1 (FUS) gene rearrangement with non-ETS gene-partner. Clinical, morphological and molecular genetic characteristics of these groups of tumors will be described below

Саркома Юинга – высокозлокачественная мелкокруглоклеточная опухоль, обладающая уникальной перестройкой гена EWSR1 (FUS) с генами-партнерами семейства ETS. Опухоли, обладающие морфологическими характеристиками саркомы Юинга, но не имеющие патогномоничной перестройки, входят в группу недифференцированных мелкокруглоклеточных опухолей костей и мягких тканей, куда также относятся саркомы с перестройкой генов CIC, BCOR, EWSR1 (FUS) с другими генами, не являющимися членами семейства ETS. Ниже будут изложены клинико-морфологические и молекулярно-генетические особенности данных групп злокачественных новообразований.

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