Bone and soft tissue sarcomas, tumors of the skinBone and soft tissue sarcomas, tumors of the skinСаркомы костей, мягких тканей и опухоли кожи2219-46142782-3687Publishing House ABV Press11110.17650/2070-9781-2021-13-1-32-40BONE SARCOMASСАРКОМЫ КОСТЕЙMorphological diagnosis of chondroid tumors of skull bones: аctual situationМорфологическая диагностика хондроидных опухолей костей черепа: состояние проблемыhttps://orcid.org/0000-0001-5461-7442ShekhtmanA. P.ШехтманА. П.
Russian Federation

117 Leninsky Avenue, Moscow 117997

Российская детская клиническая больница

117997 Москва, Ленинский пр-т, 117

ektozz@gmail.comhttps://orcid.org/0000-0003-0777-9152RogozhinD. V.РогожинД. В.
Russian Federation

117 Leninsky Avenue, Moscow 117997

8 block 10 and 17 Leninsky Avenue, Moscow 117049

Российская детская клиническая больница; кафедра патологической анатомии и клинической патологической анатомии лечебного факультета

117997 Москва, Ленинский пр-т, 117

117049 Москва, Ленинский пр-т, 8, корп. 10 и 17

Russian Children’s Clinical Hospital of N.I. Pirogov Russian National Research Medical University, Ministry of Healh of RussiaФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава РоссииPathology and Clinical Pathology Department of the Medical Faculty of N.I. Pirogov Russian National Research Medical University, Ministry of Healh of Russia0306202113132400206202102062021Copyright ©; 2021, Shekhtman A.P., Rogozhin D.V.Copyright ©; 2021, Шехтман А.П., Рогожин Д.В.2021Shekhtman A.P., Rogozhin D.V.Шехтман А.П., Рогожин Д.В.https://creativecommons.org/licenses/by/4.0https://sarbon.abvpress.ru/jour/article/view/111

Cranial chondroid tumors are a large group of benign and malignant neoplasms. The histological diagnosis plays a crucial role for treatment of patients with this pathology, especially, for cases of tumors with uncertain malignancy such as atypical cartilaginous tumor / chondrosarcoma grade I. There is no description of a unified concept of morphological diagnosis of atypical cartilaginous tumor / chondrosarcoma grade I with cranial localization in the current medical literature today. In this article we tried to reflect the actual state of the problem and emphasize the relevance of standardization of criteria for the histological assessment of cranial chondroid tumors.

Краниальные хондроидные опухоли – обширная группа как доброкачественных, так и злокачественных новообразований. Ключевую роль в лечении пациентов с данной патологией играет гистологическая диагностика опухолей с неопределенным злокачественным потенциалом, а именно: атипической хрящевой опухоли / хондросаркомы grade I. В настоящий момент в доступной медицинской литературе не описана единая концепция морфологической диагностики этого новообразования с краниальной локализацией. В данной статье мы постарались отразить состояние проблемы на сегодняшний день и подчеркнуть актуальность стандартизации критериев для гистологической оценки краниальных хондроидных опухолей.

morphological diagnosischondrosarcomachondromachordomatumors of skull basemorphological criteriachondroid tumorsморфологическая диагностикахондросаркомахондромахордомаопухоли костей черепахондроидные опухолиBloch O.G., Jian B.J., Yang I. et al. A systematic review of intracranial chondrosarcoma and survival. J Clin Neurosci 2009;16(12):1547–51. DOI: 10.1016/j.jocn.2009.05.003.Di Ieva A., Bruner E., Haider T. et al. Skull base embryology: A multidisciplinary review. Childs nerv syst 2014;30:991–1000. DOI: 10.1007/s00381-014-2411-x.Somerset H., Wilkinson C.C., Kleinschmidt-Demasters B.K. 18-year-old woman with a dural mass. Brain Pathol 2013;23(1):113–6.Golden L., Pendharkar A., Fischbein N. Chapter 7. Imaging Cranial Base Chordoma and Chondrosarcoma. In: Chordomas and Chondrosarcomas of the Skull Base and Spine. Ed. by Harsh G.R., Vaz-Guimaraes F. 2nd ed. 2018. P. 67–78.Almefty K., Pravdenkova S., Colli B.O. et al. Chordoma and chondrosarcoma: similar, but quite different, skull base tumors. Cancer 2007;110(11):2457–67. DOI: 10.1002/cncr.23073.He X., Yuan T., Yan Y. et al. Unique Image Characteristics of an Occipital Primary Chondroblastic Osteosarcoma: A Rare Case Report and a Brief Literature Review. J Neurol Surg Rep 2017;78(2): e77–e80. DOI: 10.1055/s-0037-1601876.Brackmann D.E., Teufert K.B. Chondrosarcoma of the skull base: long-term follow-up. Otol Neurotol 2006;27(7): 981–91. DOI: 10.1097/01.mao.0000233812.48800.b4.Rosenberg A.E., Nielsen G.P., Keel S.B. et al. Chondrosarcoma of the base of the skull: a clinicopathologic study of 200 cases with emphasis on its distinction from chordoma. Am J Surg Pathol 1999;23(11):1370–8. DOI: 10.1097/00000478-199911000-00007.Gelderblom H., Hogendoorn P.C., Dijkstra S.D. et al. The clinical approach towards chondrosarcoma. Oncologist 2008;13(3):320–9. DOI: 10.1634/theoncologist.2007-0237.Konovalov A., Shekhtman O., Shekhtman A.P. et al. Chondrosarcoma of the Skull Base: A Case Study and Literature Review. Cureus 2020;12(12):e12412. DOI: 10.7759/cureus.12412.Fletcher C.D.M., Hogendoorn P., Mertens F. WHO Classification of Tumors of Soft Tissue and Bone. Lyon, 2013:321–4.Golbin D.A., Ektova A.P., Demin M.O. et al. Chondromesenchymal Hamartoma with Skull Base and Orbital Involvement: Case Presentation. Cureus 2018;10(6):e2892. DOI: 10.7759/cureus.2892.Otto B.A., Jacob A., Klein M.J., Welling D.B. Chondromyxoid fibroma of the temporal bone: case report and review of the literature. Ann Otol Rhinol Laryngol 2007;116(12):922–7. DOI: 10.12998/wjcc.v6.i16.1210.Carter J.M., Inwards C.Y. Conventional chondrosarcoma: old controversies and new insights. Diagn Histopathol 2014;20(5):181–9.Mott F. Chondrosarcoma springing from the sella turcica. Arch Neurol Psychiat 1899;1:432–3.Inwards C.Y. Update on cartilage forming tumors of the head and neck. Head Neck Pathol 2007;1(1):67–74. DOI: 10.1007/s12105-007-0015-4.Chebib I., Hornicek F.J., Bredella M.A. et al. Histologic variants of chondrosarcoma. Diagnostic Histopathology 2014;20(5):172–80.Lugowska I., Teterycz P., Mikula M. et al. IDH1/2 Mutations Predict Shorter Survival in Chondrosarcoma. J Cancer 2018;9(6):998–1005. DOI: 10.7150/jca.22915.Konovalov A.N., Sidorkin D.V., Shkarubo A.N. Chordomas of the skull base and craniovertebral junction. Moscow, 2014. 276 р. (In Russ.).Коновалов А.Н., Сидоркин Д.В., Шкарубо А.Н. и др. Хордомы основания черепа и краниовертебрального перехода. М., 2014. 276 с.Nielsen G.P., Rosenberg A.E., Deshpande V. et al. Chordoma. In: Bone. Diagnostic Pathology. Ed. by Nielsen G.P., Rosenberg A.E., Deshpande V. et al. 2nd ed. Elsevier, 2017. P. 242–53. DOI: 10.1155/2016/2187290.Kerr D.A., Lopez H.U., Deshpande V. et al. Molecular distinction of chondrosarcoma from chondroblastic osteosarcoma through IDH1/2 mutations. Am J Surg Pathol 2013;37(6):787–95. DOI: 10.1097/PAS.0b013e31827ab703.Fletcher C.D.M. World Health Organization., International Agency for Research on Cancer. WHO classification of tumours of soft tissue and bone. 4th ed. Lyon: IARC Press, 2013. 468 p.Eefting D., Schrage Y.M., Geirnaerdt M.J. et al. Assessment of interobserver variability and histologic parameters to improve reliability in classification and grading of central cartilaginous tumors. Am J Surg Pathol. 2009;33(1):50–7. DOI: 10.1097/PAS.0b013e31817eec2b.Kim M.-J., Cho K.J., Ayala A.G., Ro J.Y. Chondrosarcoma: with updates on molecular genetics. Sarcoma 2011:405437. DOI: 10.1155/2011/405437.