Bone and soft tissue sarcomas, tumors of the skinBone and soft tissue sarcomas, tumors of the skinСаркомы костей, мягких тканей и опухоли кожи2219-46142782-3687Publishing House ABV Press169BONE SARCOMASСАРКОМЫ КОСТЕЙRole of receptor-ligand system in giant cell tumorРоль VEGF рецептор-лигандной системы при гигантоклеточной опухоликостиStepanovaE. V.СтепановаЕ. В.
Russian Federation
e_stepanova@nm.ruMusaevE. R.МусаевЭ. Р.
Russian Federation
SushencovE. A.СушенцовЕ. А.
Russian Federation
PetrovichevN. N.ПетровичевН. Н.
Russian Federation
AlievM. D.АлиевМ. Д.
Russian Federation
LichinizerM. R.ЛичиницерМ. Р.
Russian Federation
N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical SciencesРоссийский онкологический научный центр им. Н.Н. Блохина РАМН1106201023343811012022Copyright ©; 2010, Stepanova E.V., Musaev E.R., Sushencov E.A., Petrovichev N.N., Aliev M.D., Lichinizer M.R.Copyright ©; 2010, Степанова Е.В., Мусаев Э.Р., Сушенцов Е.А., Петровичев Н.Н., Алиев М.Д., Личиницер М.Р.2010Stepanova E.V., Musaev E.R., Sushencov E.A., Petrovichev N.N., Aliev M.D., Lichinizer M.R.Степанова Е.В., Мусаев Э.Р., Сушенцов Е.А., Петровичев Н.Н., Алиев М.Д., Личиницер М.Р.https://creativecommons.org/licenses/by/4.0https://sarbon.abvpress.ru/jour/article/view/169

Expression of VEGF and its receptors and proliferative activities were studied in cells of giant cell tumor of the bone. Immuno-histochemical analysis was performed on 11 formalin-fixed, formalin-embedded samples of giant cell tumor of the bone. VEGF and its receptors VEGFR-1 (Flt-1) and VEGFR-2 (Flk-l/KDR) was detected in all specimens and all cellular components such as reactive osteoclast-like giant cells and stromal cells. Ki-67 expression was limited to the mononuclear stromal cell component of the tumors. The high degree of expression Flk-1 and Flt-1 significantly correlated with high proliferative activity of the tumor (≥5 %) (p=0,031 for Flk-1 and p=0,048 for Flt-1). These results suggest that VEGF receptor-ligand system might play a role in the pathogenesis of giant cell tumor of the bone. The further research should help to explain a unique nature and cell interaction mechanisms of this tumor.

Было проведено исследование экспрессии VEGF и его рецепторов и пролиферативной активности в клетках гигантоклеточной опухоли кости. Иммуногистохимическим методом было исследовано 11 фиксированных в формалине, заключенных в формалин образцов гигантоклеточной опухоли. VEGF и его рецепторы VEGFR-1 (Fit-1) and VEGFR-2 (Flk-1 /KDR) были обнаружены во всех случаях и во всех клеточных типах, как на многоядерных остеокласт-подобных клетках, так и на стромальных. Стромальный компонент опухоли был единственным типом клеток, окрашивающихся на Кi-67. Высокая степень экспрессии Flk-І и FIt-І значимо коррелировала с высокой пролиферативной активностью (≥5%) (р=0,031 и р=0,048, соответственно). Полученные результаты предполагают важную роль VEGF рецептор-лигандной системы в патогенезе гигантоклеточной опухоли кости. Дальнейшие исследования в этой области должны помочь прояснить уникальную природу и механизмы взаимодействий клеток этой опухоли.

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