Bone and soft tissue sarcomas, tumors of the skinBone and soft tissue sarcomas, tumors of the skinСаркомы костей, мягких тканей и опухоли кожи2219-46142782-3687Publishing House ABV Press17BONE SARCOMASСАРКОМЫ КОСТЕЙPrimary malignant tumors of the spine. Literature reviewПервичные злокачественные опухоли позвоночного столба. Обзор литературыKabardaevR. M.КабардаевР. М.
Russian Federation
ruslan-kabardaev@mail.ruMusaevE. R.МусаевЭ. Р.
Russian Federation
ValievA. K.ВалиевА. К.
Russian Federation
KulagaA. V.КулагаА. В.
Russian Federation
FGBU «National Medical Research Center of Oncology named after N.N. Blokhin» of the Ministry of Health of RussiaФГБУ «НМИЦ онкологии им. Н.Н. Блохина» Минздрава России16042018101101716042021Copyright ©; 2018, Kabardaev R.M., Musaev E.R., Valiev A.K., Kulaga A.V.Copyright ©; 2018, Кабардаев Р.М., Мусаев Э.Р., Валиев А.К., Кулага А.В.2018Kabardaev R.M., Musaev E.R., Valiev A.K., Kulaga A.V.Кабардаев Р.М., Мусаев Э.Р., Валиев А.К., Кулага А.В.https://creativecommons.org/licenses/by/4.0https://sarbon.abvpress.ru/jour/article/view/17

Primary spinal tumors are relatively rare nosologies in the structure of oncopathology which constitute about 0,4% of all malignant neoplasms. Despite the obvious successes of recent decades in the treatment of bone sarcoma, the results of therapy for primary spinal tumors due to anatomical localization, difficulties in diagnosing and the complexity of the surgical intervention remain unsatisfactory. Our article contains a review of the literature devoted to the main primary malignant tumors of the spinal column.

Первичные опухоли позвоночника относительно редкие нозологии в структуре онкопатологии, которые составляют около 0,4% всех злокачественных новообразований. Несмотря на очевидные успехи последних десятилетий в лечении сарком костей, результаты терапии первичных опухолей позвоночника в силу анатомической локализации, трудности постановки диагноза и сложности хирургического вмешательства остаются неудовлетворительными. В нашей статье приводится обзор литературы, посвященный основным первичным злокачественным опухолям позвоночного столба.

tumors of the spineosteosarcomachondrosarcomaEwing’s sarcomamalignant fibrous histiocytomachordomaопухоли позвоночникаостеосаркомахондросаркомасаркома Юингазлокачественная фиброзная гистиоцитомахордомаЗаридзе ДГ Архив патологии. 2003; (2): 53-61.Трапезников НН, Еремина ЛА, Амирасланов АТ и соавт. Опухоли костей. М., 1986: 7-19.Bacci G, Picci P, Gherlinzoni F et al. Localized Ewing’s sarcoma of bone: Ten years’ experience at the Instituto Ortopedico Rizzoli in 124 cases treated with multimodal therapy. Eur J Cancer Clin Oncol. 1985; 21: 163-173.Gopalakrishnan CV, Shrivastava A, Easwer HV et al. Primary Ewing’s sarcoma of the spine presenting as acute paraplegia. J Pediatr Neurosci. 2012; 7(1): 64-66.Алиев МД, Тепляков ВВ, Калистов ВЕ и соавт. Современные подходы к хирургическому лечению метастазов злокачественных опухолей в кости. Практ. онкол. 2001; (1): 39-43.Нейштадт ЭЛ, Маркочев АБ. Опухоли и опухолеподобные заболевания. Изд-во Фолиант. 2007: 7-15.Yin K, Liao Q, Zhong D et al. Meta-analysis of limb salvage versus amputation for treating high-grade and localized osteosarcoma in patients with pathological fracture. Exp Ther Med. 2012; 4: 889-894.Takeuchi A, Lewis VO, Satcher RL et al. What are the factors that affect survival and relapse after local recurrence of osteosarcoma? Clin Orthop Relat Res. 2014; 472: 3188-3195.Esiashvili N, Goodman M, Marcus RJ. Changes in incidence and survival of Ewing sarcoma patients over the past 3 decades: surveillance epidemiology and end results data. J Pediatr He-matol Oncol. 2008; 30: 425-443.Bakhshi S, Radhakrishnan V. Prognostic markers in osteosarcoma. Expert Rev Anticancer Ther. 2010; 10: 271-287.Dreghorn CR, Newman RJ, Hardy GJ et al. Primary tumors of the axial skeleton. Experience of the Leeds Regional Bone Tumor Registry. Spine (Phila Pa 1976). 1990; 15(2): 137-140.Kelley SP, Ashford RU, Rao AS et al. Primary bone tumors of the spine: a 42-year survey from the Leeds Regional Bone Tumor Registry. Eur Spine J. 2007; 16(3): 405-409.Мусаев ЭР. Первичные опухоли позвоночника: обзор литературы. Практ. онкол. 2010; (11)1: 19-24.Fischgrund J. Orthopaedic Knowledge Update 9. American Academy of Orthopaedic Surgeons. 2008: 635.Katonis P, Datsis G, Karantanas A et al. Spinal Osteosarcoma. Clin Med Insights Oncol. 2013; 7: 199-208.Ozaki T, Flege S, Liljenqvist U et al. Osteosarcoma of the spine: experience of the Cooperative Osteosarcoma Study Group. Cancer. 2002; 94(4): 1069-1077.DeLaney TF, Park L, Goldberg SI et al. Radiotherapy for local control of osteosarcoma. Int J Radiat Oncol Biol Phys. 2005; 61(2): 492-498.Sofka CM, Ciavarra G, Saboeiro G et al. Paget’s disease of the spine and secondary osteosarcoma. Hss J. 2006; 2(2): 188-190.Schwab J, Gasbarrini A, Bandiera S et al. Osteosarcoma of the mobile spine. Spine (Phila Pa 1976). 2012; 37(6): E381-E386.Lerma E, Tani E, Bzosjo O. Diagnosis and grading of chondrosarcomas on FNA biopsy material. Diagn Cytopathol. 2003; (28): 13-17.Arockiaraj J, Venkatesh K, Amritanand R et al. Chondrosarcoma of the spinous process: a rare presentation. Asian Spine Journal. 2012; 6(4): 279-283. DOI: 10.4184/asj.2012.6.4.279.Adimonye A. A Rare and Interesting Case of a Massive Secondary Spinal Chondrosarcoma and Review of the Literature. Case Rep Orthop. 2015; 2015: 386482. DOI: 10.1155/2015/386482.Schoenfeld AJ, Hornicek FJ, Pedlow FX et al. Chondrosarcoma of the mobile spine: a review of 21 cases treated at a single center. Spine. 2012; 37(2): 119-126. DOI: 10.1097/brs.0b013e31823d2143.Matsuda Y, Sakayama K, Sugawara Y et al. Mesenchymal chondrosarcoma treated with total en bloc spondylectomy for 2 consecutive lumbar vertebrae resulted in continuous disease-free survival for more than 5 years: case report. Spine. 2006; 31(8): E231-E236.Lloret I, Server A, Bjerkehagen B. Primary spinal chondrosarcoma: Radiologic findings with pathologic correlation. Acta Radiol. 2006; 47: 77-84.Riedel RF, Larrier N, Dodd L et al. The clinical management of chondrosarcoma. Current Treatment Options in Oncology. 2009; 10(1-2): 94-106. DOI: 10.1007/s11864-009-0088.Herget GW, Strohm P, Rottenburger C et al. Insights into Enchondroma, Enchondromatosis and the risk of secondary Chondrosarcoma. Review of the literature with an emphasis on the clinical behavior, radiology, malignant transformation and the follow up. Neoplasma. 2014; 61(4): 365-378.Ren C, Zeng J, Song Y et al. Recurrent primary lumbar vertebra chondrosarcoma: marginal resection and Iodine-125 seed therapy. Indian Journal of Orthopaedics. 2014; 48(2): 216-219. DOI: 10.4103/0019-5413.128772.Boriani S, de Lure F, Bandiera S et al. Chondrosarcoma of the mobile spine: report on 22 cases. Spine. 2000; 25(7): 804-812.Hirsh LF, Thanki A, Spector HB. Primary spinal chondrosarcoma with eighteen-year follow-up: Case report and literature review. Neurosurgery. 1984; 14: 747-749.Strike SA, McCarthy EF. Chondrosarcoma of the spine: a series of 16 cases and a review of the literature. The Iowa orthopaedic journal. 2011; 31: 154-159.Goda JS, Ferguson PC, Sullivan BO et al. High-risk extracranial chondrosarcoma. Cancer. 2011; 117: 2513-2519.Hamilton AJ, Lulu B, Stea B et al. The use of gold foil wrapping for radiation protection of the spinal-cord for recurrent tumor-therapy. Int J Radiat Oncol Biol Phys. 1995; 32: 507-511.Shives TC, McLeod RA, Unni KK et al. Chondrosarcoma of the spine. The Journal of Bone and Joint Surgery - American Volume. 1989; 71(8): 1158-1165.DeLaney TF, Liebsch NJ, Pedlow FX et al. Long-term results of Phase II study of high dose photon/proton radiotherapy in the management of spine chordomas, chondrosarcomas, and other sarcomas. Journal of Surgical Oncology. 2014; 110(2): 115-122. DOI: 10.1002/jso.23617.Соловьев ЮН. Саркома Юинга. Вопросы онкологии. 2002; (1): 7-11.Kim SW, Shin H. Primary intradural extraosseous Ewing’s Sarcoma. J Korean Neuroserg Soc. 2009; 45(3): 179-181.Kazanci A, Gurcan O, Gurcay AG et al. Primary Ewing sarcoma in spinal epidural space: report of three cases and review of the literature. Primer Spinal Epidural Ewing Sarkoma. 2015; 32(1): 250-261.Wu G, Ghimire P, Zhu L et al. Magnetic resonance imaging characteristics of primary intraspinal peripheral primitive neuroectodermal tumor. Can Assoc Radiol J. 2013; 64(3): 240-245.Bustoros M, Thomas C, Frenster J et al. Adult Primary Spinal Epidural Extraosseous Ewing’s Sarcoma: A Case Report and Review of the Literature. Case Rep Neurol Med. 2016; 2016: 1217428. DOI: 10.1155/2016/1217428.Saeedinia S, Nouri M, Alimohammadi M et al. Primary spinal extradural Ewing’s sarcoma (primitive neuroectodermal tumor): report of a case and meta-analysis of the reported cases in the literature. Surg Neurol Int. 2012; 3: 55. DOI: 10.4103/2152-7806.96154.Schmidt D, Herrmann C, Jurgens H et al. Malignant peripheral neuroectodermal tumor and its necessary distinction from Ewing’s sarcoma. A report from the Kiel Pediatric Tumor Registry. Cancer.1991; 68: 2251-2259.Zhu Q, Zhang J, Xiao J. Primary dumbbell-shaped Ewing’s sarcoma of the cervical vertebra in adults: four case reports and literature review. Oncology Letters. 2012; 3(3): 721-725. DOI: 10.3892/ol.2012.550.Guobin H, Lingjing G, Xianglian D et al. Clinical, pathological, and imaging characteristics of primitive neuroectodermal tumors of the spine. Diagn Interv Radiol. 2014; 20(2): 168-171.Pancucci G, Simal-Julian JA, Plaza-Ramirez E et al. Primary extraosseous intradural spinal Ewing’s sarcoma: report of two cases. Acta Neurochir (Wien). 2013; 155: 1229-1234.Feng H, Wang J, Guo P et al. Revision Surgical Treatment of a Second Lumbar Ewing Sarcoma. Medicine (Baltimore). 2015; 94(30): e1190.Kobayashi S, Takahashi J, Sakashita K et al. Ewing sarcoma of the thoracic epidural space in a young child. Eur Spine J. 2013; 22 suppl 3: S373-S379.Kim SW, Shin H. Primary intradural extraosseous Ewing’s Sarcoma. J Korean Neuroserg Soc. 2009; 45(3): 179-181.Bustoros M, Thomas C, Frenster J et al. Adult Primary Spinal Epidural Extraosseous Ewing’s Sarcoma: A Case Report and Review of the Literature. Case Rep Neurol Med. 2016; 2016: 1217428. DOI: 10.1155/2016/1217428.Gopalakrishnan CV, Shrivastava A, Easwer HV et al. Primary Ewing’s sarcoma of the spine presenting as acute paraplegia. J Pediatr Neurosci. 2012; 7(1): 64-66.Aliev M, Musaev E, Sushentsov E, Valiev A. Indication for surgical treatment of metastatic lesions of spine. Abstr. EM-SOS. Moscow, 2006.Feldman F, Noman D. Primary malignant fibrous histiocytoma. Radiology. 1972; (104): 497-508.Somasundaram A, Wicks RT, Lata AL et al. En bloc spon-dylectomy for primary malignant fibrous histiocytoma of the thoracic spine with aortic involvement: case report. J Neurosurg Spine. 2015; 22(4): 399-405. DOI: 10.3171/2014.9.Karantanas AH, Hytiroglou P, Zibis AH et al. Malignant fibrous histiocytoma of the spine causing spinal neural foramen widening. Comput Med Imaging Graph. 2000; 24: 329-332.Akpinar A, Ozdemir CO, Ucler N et al. Storiform-Pleomorphic Type of Multifocal Malignant Fibrous Histiocytoma of the Lumbar Spine. Am J Case Rep. 2014; 15: 565-568.Maillefert JF, Guy F, Coudert B et al. Multifocal malignant fibrous histiocytoma of the spine. Rev Rhum Engl Ed. 1997; 64(4): 274-277.Teng H, Xinghai Y, Wei H et al. Malignant fibrous histiocytoma of the spine: a series of 13 clinical case reports and review of 17 published cases. Spine (Phila Pa 1976). 2011; 36(22): E1453-1462. DOI: 10.1097/BRS.0b013e318203e292.Sereno M, Merino M, Aguayo C et al. A major response to trabectedin in metastatic malignant fibrous histiocytoma of the vertebra: a case report and review of the literature. Tumori. 2013; 99: e43-48.Gallia GL, Suk I, Witham TF et al. Lumbopelvic reconstruction after combined L5 spondylectomy and total sacrectomy for en bloc resection of a malignant fibrous histiocytoma. Neurosurgery. 2010; 67(2): E498-502. DOI: 10.1227/01.NEU.0000382972.15422.10.Nadeem SQ, Feun LG, Bruce-Gregorios JH et al. Post radiation sarcoma (malignant fibrous histiocytoma) of the cervical spine following ependymoma (a case report). J Neurooncol. 1991; 11(3): 263-268.Miettinen M, Lehto VP, Virtanen I. Malignant fibrous histiocytoma within a recurrent chordoma. A light microscopic, electron microscopic, and immunohistochemical study. Am J Clin Pathol. 1984; 82(6): 738-743.Fukuda T, Aihara T, Ban S et al. Sacrococcygeal chordoma with a malignant spindle cell component. A report of two autopsy cases with a review of the literature. Acta Pathol Jpn. 1992; 42(6): 448-453.Crapanzano J, Ali S, Ginsberg M et al. Chordoma: study with histologic and radiologic correlation. Acta cytol. 2000; (44): 304.Bydon M, Papadimitriou K, Witham T et al. Novel therapeutic targets in chordoma. Expert Opin Ther Targets. 2012; 16: 1139-1143.Bompas E, Le Cesne A, Tresch-Bruneel E et al. Sorafenib in patients with locally advanced and metastatic chordomas: a phase II trial of the French Sarcoma Group (GSF/GETO). Ann Oncol. 2015; 26: 2168-2173.Mukherjee D, Chaichana KL, Adogwa O et al. Association of extent of local tumor invasion and survival in patients with malignant primary osseous spinal neoplasms from the Surveillance, Epidemiology, and End Results (SEER) database. World Neurosurg. 2011; 76: 580-585.Kay P, Salomao D, Nascimento A et al. Chordoma: Cytomor-phologic finding of 14 cases diagnosed by fine needle aspiration biopsy. Acta cytol. 2000; (44): 905-906.Kayani B, Hanna SA, Sewell MD et al. A review of the surgical management of sacral chordoma. Eur J Surg Oncol. 2014; 40: 1412-1420.Kayani B, Sewell MD, Tan KA et al. Prognostic factors in the operative management of sacral chordomas. World Neurosurg. 2015; 84: 1354-1361.Zou MX, Peng AB, Lv GH et al. Expression of programmed death-1 ligand (PD-L1) in tumor-infiltrating lymphocytes is associated with favorable spinal chordoma prognosis. Am J Transl Res. 2016; 8(7): 3274-3287.Bergh P, Kindblom LG, Gunterberg B et al. Prognostic factors in chordoma of the sacrum and mobile spine: a study of 39 patients. Cancer. 2000; 88: 2122-2134.Baratti D, Gronchi A, Pennacchioli E et al. Chordoma: natural history and results in 28 patients treated at a single institution. Ann Surg Oncol. 2003; 10: 291-296.Chugh R, Tawbi H, Lucas DR et al. Chordoma: the nonsarcoma primary bone tumor. Oncologist. 2007; 12: 1344-50.10.1634/theoncologist.12-11-1344.Aleksic T, Browning AL, Woodward M et al. Durable Response of Spinal Chordoma to Combined Inhibition of IGF-1R and EGFR. Front Oncol. 2016; 6: 98. DOI: 10.3389/fonc.2016.00098.Garofalo F, Christoforidis D, di Summa PG et al. The unresolved case of sacral chordoma: from misdiagnosis to challenging surgery and medical therapy resistance. Ann Coloproctol. 2014; 30: 122-31.10.3393/ ac.2014.30.3.Tauziède-Espariat A, Bresson D, Polivka M et al. Prognostic and therapeutic markers in chordomas: a study of 287 tumors. J Neuropathol Exp Neurol. (2016).10.1093/jnen/nlv010.McMaster ML, Goldstein AM, Bromley CM et al. Chordoma: incidence and survival patterns in the United States, 1973-1995. Cancer Causes Control. 2001; 12: 1-11.Choi D, Melcher R, Harms J et al. Outcome of 132 operations in 97 patients with chordomas of the craniocervical junction and upper cervical spine. Neurosurgery. 2010; 66: 59-65.Aleksic T, Browning AL, Woodward M et al. Durable Response of Spinal Chordoma to Combined Inhibition of IGF-1R and EGFR. Front Oncol. 2016; 6: 98. DOI: 10.3389/ fonc.2016.00098.