Bone and soft tissue sarcomas, tumors of the skinBone and soft tissue sarcomas, tumors of the skinСаркомы костей, мягких тканей и опухоли кожи2219-46142782-3687Publishing House ABV Press187EXPERIMENTAL ONCOLOGYЭКСПЕРИМЕНТАЛЬНАЯ ОНКОЛОГИЯMolecular biomarkers oftypel neurofibromatosisМолекулярно-биологические маркеры неврофиброматоза I типаStepanovaE. V.СтепановаЕ. В.
Russian Federation
e_stepanova@nm.ruLichinitserM. R.ЛичиницерМ. Р.
Russian Federation
BokhyanB. Y.БохянВ. Ю.
Russian Federation
FedenkoA. A.ФеденкоА. А.
Russian Federation
CharatishviliT. K.ХаратишвилиТ. К.
Russian Federation
AlievM. D.АлиевМ. Д.
Russian Federation
N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical SciencesРоссийский онкологический научный центр им. Н.Н. Блохина РАМН1111201024555811012022Copyright ©; 2010, Stepanova E.V., Lichinitser M.R., Bokhyan B.Y., Fedenko A.A., Charatishvili T.K., Aliev M.D.Copyright ©; 2010, Степанова Е.В., Личиницер М.Р., Бохян В.Ю., Феденко А.А., Харатишвили Т.К., Алиев М.Д.2010Stepanova E.V., Lichinitser M.R., Bokhyan B.Y., Fedenko A.A., Charatishvili T.K., Aliev M.D.Степанова Е.В., Личиницер М.Р., Бохян В.Ю., Феденко А.А., Харатишвили Т.К., Алиев М.Д.https://creativecommons.org/licenses/by/4.0https://sarbon.abvpress.ru/jour/article/view/187

Neurofibromatosis type I is a autosomal dominant hereditary disorder caused by NF1 gene mutations. The main molecular mechanisms contributes to tumor formation in neurofibromatosis type I is angiogenesis stimulation and ras, AKT-mTOR signaling pathways activation. We show that these tumors expressed c-kit and VEGF. Information about clinical trials of target therapy for neurofibromatosis I type patient treatment is cited.

Нейрофиброматоз I типа - аутосомно-доминантное наследственное заболевание, связанное с мутациями в гене NF1. Основными молекулярными механизмами развития опухолей при нейрофиброматозе I типа является стимуляция ангиогенеза и сигнальных путей ras, AKT-mTOR. Нами показано, что в этих опухолях экспрессируется c-kit и VEGF. Приводятся данные о клинических испытаниях таргетных препаратов у больных нейрофиброматозом I типа.

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