Bone and soft tissue sarcomas, tumors of the skinBone and soft tissue sarcomas, tumors of the skinСаркомы костей, мягких тканей и опухоли кожи2219-46142782-3687Publishing House ABV Press199ArticlesСтатьиAlkylguanine-DNA alkyltransferase as predictive factor of efficacy of dacarbazine+cisplatin+nidran regimen in patients with metastatic skin mela- nomaАлкилгуанин алкилтрансфераза как фактор предсказания эффек- тивности режима дакарбазин+цисплатин+нидран у больных мета- статической меланомой кожиСтепановаЕ. В.
Russian Federation
e_stepanova@nm.ruАбрамовМ. Е.
Russian Federation
БарышниковА. Ю.
Russian Federation
ЛичиницерМ. Р.
Russian Federation
StepanovaE. V.
Russian Federation
AbramovM. E.
Russian Federation
BaryshnikovA. Yu.
Russian Federation
LichinitserM. R.
Russian Federation
Российский онкологический научный центр им. Н.Н. Блохина РАМНN.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Science1101201131505411012022Copyright ©; 2011, ., ., ., ., Stepanova E.V., Abramov M.E., Baryshnikov A.Y., Lichinitser M.R.Copyright ©; 2011, Степанова Е.В., Абрамов М.Е., Барышников А.Ю., Личиницер М.Р., Stepanova E., Abramov M., Baryshnikov A., Lichinitser M.2011., ., ., ., Stepanova E.V., Abramov M.E., Baryshnikov A.Y., Lichinitser M.R.Степанова Е.В., Абрамов М.Е., Барышников А.Ю., Личиницер М.Р., Stepanova E., Abramov M., Baryshnikov A., Lichinitser M.https://creativecommons.org/licenses/by/4.0https://sarbon.abvpress.ru/jour/article/view/199

Background. The goal of this study was to analyze significance of AGT expression as predictive marker of efficacy of Dacar bazine+Cisplatin+Nidran regimen in patients with metastatic skin melanoma Methods. 26 patients with metastatic skin melanoma were enrolled in the retrospective study. Immunohistochemical analysis of AGT expression was performed on paraffin-embedded tissue sections of primary tumor or available metastasis. Results. High AGT expression in tumor cells was associated with low efficacy of Dacarbazine+Cisplatin+Nidran regimen. Disease progression was observed in 85,7% patient with AGT-positive tumor and 29,4% - AGT-negative (р=0,023). There was a not significant difference of time without progression between two groups of patients. Conclusion. AGT expression could be potentially useful tool for predicting response of metastatic melanoma patients to Dacarbazine+Cisplatin+Nidran regimen.

Цельработы. Целью работы было изучить значение экспрессии АГТ в опухолевых клетках для предсказания эффективности режима с включением дакарбазина, цисплатина и нидрана для лечения метастатической меланомы кожи. Материалы и методы. В ретроспективное исследование включены 26 больных метастатической меланомой кожи. Было проведено исследование экспрессии АГТ иммуногистохимическим методом в парафиновых блоках опухоли (первичный очаг или доступный метастаз). Результаты. Экспрессия АГТ в опухоли ассоциировалась с низким эффектом режима дакарбазин+цисплатин+ нидран. Прогрессирование наблюдалось у 85,7% больных с АГТ-положительными опухолями и 29,4% - с АГТ-от-рицательными (р=0,023). Различия в выживаемости без прогрессировать больных не достигали достоверности. Заключение. Экспрессия АГТ может рассматриваться как перспективный маркер для предсказания эффективности режима дакарбазин+цисплатин+нидран у больных метастатической меланомой кожи.

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