Bone and soft tissue sarcomas, tumors of the skinBone and soft tissue sarcomas, tumors of the skinСаркомы костей, мягких тканей и опухоли кожи2219-46142782-3687Publishing House ABV Press20SOFT TISSUE SARCOMASСАРКОМЫ МЯГКИХ ТКАНЕЙTreatment of breast sarcomas. Review of literatureЛечение сарком молочной железы. Обзор литературыSopromadzeS. V.СопромадзеС. В.
Russian Federation
sofi.s-m@mail.ruSobolevskyV. A.СоболевскийВ. А.
Russian Federation
KrochinaO. V.КрохинаО. В.
Russian Federation
FedenkoA. A.ФеденкоА. А.
Russian Federation
FGBU «National Medical Research Center of Oncology named after N.N. Blokhin» of the Ministry of Health of RussiaФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава РоссииFederal State Budgetary Educational Institution of Higher Education «A.I. Yevdokimov Moscow State University of Medicine and Dentistry» of the Ministry of Healthcare of the Russian FederationФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава РоссииFGBU «National Medical Research Center of Oncology named after N.N. Blokhin» of the Ministry of Health of RussiaФГБУ «НМИЦ онкологии им. Н.Н. Блохина» Минздрава РоссииFGBU «National Medical Research Center of Oncology named after N.N. Blokhin» of the Ministry of Health of Russia16042018101333816042021Copyright ©; 2018, Sopromadze S.V., Sobolevsky V.A., Krochina O.V., Fedenko A.A.Copyright ©; 2018, Сопромадзе С.В., Соболевский В.А., Крохина О.В., Феденко А.А.2018Sopromadze S.V., Sobolevsky V.A., Krochina O.V., Fedenko A.A.Сопромадзе С.В., Соболевский В.А., Крохина О.В., Феденко А.А.https://creativecommons.org/licenses/by/4.0https://sarbon.abvpress.ru/jour/article/view/20

Breast sarcomas are spectrum of heterogeneous sarcomas in breast and the optimal treatment is still under discussion. We retrospectively reviewed 51 patient with BS between 1999 and 2014 in N.N. Blokhin Russian Cancer Research Center Ministry of Health of the Russian Federation. With median follow up of 86,4 months, 43,14% of patients (22/51) developed local recurrence and metastasis. Five year recurrence free survival and OS rate were 37,5 and 56,2%, respectively. Disease stage and local recurrence were indicated as unfavorable prognostic factors. Surgery remains a crucial treatment for breast sarcomas. Mastectomy is not routinely necessary if clear margin could be achieved by local excision.

Саркомы молочной железы представляют собой чрезвычайно редкую и гетерогенную группу злокачественных опухолей молочной железы, которые встречаются в среднем в 0,2-0,6% от всех злокачественных заболеваний молочной железы и выявляются практически в любом возрасте. основу нашей работы составил ретроспективный анализ клинических наблюдений 51 пациентки с саркомами молочной железы, проходившей обследование и лечение в период с 1999 по 2017 г. в ФГБУ НМИЦ онкологии им. Н.Н. Блохина. Пяти- и 10-летняя общая и безрецидивная выживаемость у пациенток с саркомами молочной железы в общей группе составила 56,25, 8,25% и 37,5 и 3,1% соответственно (медиана выживаемости - 86,4 мес). При медиане наблюдения 86,4 мес у 43,14% (22/51) пациентов были выявлены рецидив заболевания и метастазы. В результате многофакторного анализа были отобраны наиболее значимые факторы прогноза: стадия заболевания (включая размер опухоли, гистологический подтип опухоли и степень злокачественности), возникновение рецидива. основной метод лечения сарком молочной железы - хирургический. При соблюдении чистого края резекции возможно выполнение органосохранных и реконструктивно-пластических операций. Комбинированный подход необходим при лечении сарком высокой степени злокачественности с учетом морфологических и иммуногистохимических параметров опухоли.

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