Bone and soft tissue sarcomas, tumors of the skinBone and soft tissue sarcomas, tumors of the skinСаркомы костей, мягких тканей и опухоли кожи2219-46142782-3687Publishing House ABV Press254ArticlesСтатьиBASIC PRINCIPLES OF DYNAMIC CONTRAST-ENHANCED MAGNETIC RESONANCE IMAGING IN THE EVALUATION OF THE PREOPERATIVE CHEMOTHERAPY IN PATIENTS WITH BONE AND SOFT TISSUE SARCOMASОсновы методики контрастной МРТ В ОЦЕНКЕ ЭФФЕКТИВНОСТИ ПРЕДОПЕРАЦИОННОЙ ХИМИОТЕРАПИИ У БОЛЬНЫХ С САРКОМАМИ КОСТЕЙ И МЯГКИХ ТКАНЕЙБлудовА. Б.
Russian Federation
ЗамогильнаяЯ. А.
Russian Federation
yzamogilnaya@gmail.comНередА. С.
Russian Federation
КочергинаН. В.
Russian Federation
БохянБ. Ю.
Russian Federation
МачакГ. Н.
Russian Federation
ФеденкоА. А.
Russian Federation
АнуроваО. А.
Russian Federation
ЗаспаО. А.
Russian Federation
BludovA. B.
Russian Federation
ZamogilnayaY. A.
Russian Federation
NeredA. S.
Russian Federation
KocherginaN. V.
Russian Federation
BokhyanB. Y.
Russian Federation
MachakG. N.
Russian Federation
FedenkoA. A.
Russian Federation
AnurovaO. A.
Russian Federation
ZaspaO. A.
Russian Federation
Российский онкологический научный центр им. Н.Н. Блохина РАМНN.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical SciencesРМАПОRussian Medical Academy of Postgraduate EducationФГУ Московский научно-исследовательский онкологический институт им. П.А. Герцена Минздравсоцразвития РоссииP.A Herzen Moscow Research Oncological Institute1111201134415011012022Copyright ©; 2011, ., ., ., ., ., ., ., ., ., Bludov A.B., Zamogilnaya Y.A., Nered A.S., Kochergina N.V., Bokhyan B.Y., Machak G.N., Fedenko A.A., Anurova O.A., Zaspa O.A.Copyright ©; 2011, Блудов А.Б., Замогильная Я.А., Неред А.С., Кочергина Н.В., Бохян Б.Ю., Мачак Г.Н., Феденко А.А., Анурова О.А., Заспа О.А., Bludov A., Zamogilnaya Y., Nered A., Kochergina N., Bokhyan B., Machak G., Fedenko A., Anurova O., Zaspa O.2011., ., ., ., ., ., ., ., ., Bludov A.B., Zamogilnaya Y.A., Nered A.S., Kochergina N.V., Bokhyan B.Y., Machak G.N., Fedenko A.A., Anurova O.A., Zaspa O.A.Блудов А.Б., Замогильная Я.А., Неред А.С., Кочергина Н.В., Бохян Б.Ю., Мачак Г.Н., Феденко А.А., Анурова О.А., Заспа О.А., Bludov A., Zamogilnaya Y., Nered A., Kochergina N., Bokhyan B., Machak G., Fedenko A., Anurova O., Zaspa O.https://creativecommons.org/licenses/by/4.0https://sarbon.abvpress.ru/jour/article/view/254

Magnetic resonance imaging (MRI) is widely used (method of choice) in therapy monitoring and in further dynamic control. MRI allows to evaluate changes in tumor size and structure during the treatment. However, as a result of heterogeneity in structure of bone and soft tissue sarcomas, these criteria don't allow to determine the effect of treatment properly in all clinical cases. This happens because this method doesn't reflect the most important criteria - the tumor vascularization and changes in vascularization during treatment. Thus, a new physiological method of MRI such as dynamic contrast-enhanced MRI (DCE MRI) is being developed. DCE MRI provides the better evaluation of response to preoperative treatment due to its ability in detection of highly vascularized zones in different sites of the tumor, which correlate with regions of viable tumor on pathologic examination. DCE MRI provides different types of analyses of tumor changes during therapy: quantitative, semi-qualitative and qualitative. The following review of literature demonstrates the basic principles of DCE MRI in assessing the efficacy of treatment in patients with bone and soft tissue sarcomas.

Магнитно-резонансная томография активно применяется (является методом выбора) для оценки эффекта проводимого лечения и дальнейшего динамического контроля. Метод позволяет оценивать размеры, а также характер изменения структуры опухоли в динамике. Однако по причине неоднородности структуры сарком костей и мягких тканей эти параметры не всегда предоставляют возможность однозначно судить об эффекте проводимого лечения, так как не отражают главную характеристику опухоли - степень васкуляризации и ее изменение в процессе лечения. Учитывая это, была разработана физиологическая методика исследования-динамическое МРТ с контрастированием. Методика косвенным образом позволяет оценивать характер васкуляризации в различных участках опухоли, что коррелирует с наличием живой опухолевой ткани при патоморфологическом исследовании. Данная методика позволяет проводить качественный, полуколичественный и количественный анализы изменений в опухоли в процессе лечения. В данном обзоре литературы приведены основные принципы методики динамического MP-исследования с контрастированием в оценке эффекта химиотерапии у больных с саркомами костей и мягких тканей.

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