Bone and soft tissue sarcomas, tumors of the skinBone and soft tissue sarcomas, tumors of the skinСаркомы костей, мягких тканей и опухоли кожи2219-46142782-3687Publishing House ABV Press255ArticlesСтатьиSYNCHRONOUS DEVELOPMENT OF LOCAL RECURRENCE AND DISTANT METASTASES IN PATIENTS WITH SOFT TISSUE SARCOMAСинхронное развитие локального рецидива и отдаленных метастазов у пациентов с саркомами мягких тканейМартынковД. В.
Russian Federation
generaloncology@rambler.ruХаратишвилиТ. К.
Russian Federation
БохянБ. Ю.
Russian Federation
ФеденкоА. А.
Russian Federation
БуровД. А.
Russian Federation
АлиевМ. Д.
Russian Federation
ПетроченкоН. С.
Russian Federation
MartynkovD. V.
Russian Federation
KharatishviliТ. К.
Russian Federation
BohyanB. Y.
Russian Federation
FedenkoA. A.
Russian Federation
BurovD. A.
Russian Federation
AlievM. D.
Russian Federation
PetrochenkoN. S.
Russian Federation
Российский онкологический научный центр им. Н.Н. Блохина РАМНN.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences1111201134515511012022Copyright ©; 2011, ., ., ., ., ., ., ., Martynkov D.V., Kharatishvili Т.К., Bohyan B.Y., Fedenko A.A., Burov D.A., Aliev M.D., Petrochenko N.S.Copyright ©; 2011, Мартынков Д.В., Харатишвили Т.К., Бохян Б.Ю., Феденко А.А., Буров Д.А., Алиев М.Д., Петроченко Н.С., Martynkov D., Kharatishvili Т., Bohyan B., Fedenko A., Burov D., Aliev M., Petrochenko N.2011., ., ., ., ., ., ., Martynkov D.V., Kharatishvili Т.К., Bohyan B.Y., Fedenko A.A., Burov D.A., Aliev M.D., Petrochenko N.S.Мартынков Д.В., Харатишвили Т.К., Бохян Б.Ю., Феденко А.А., Буров Д.А., Алиев М.Д., Петроченко Н.С., Martynkov D., Kharatishvili Т., Bohyan B., Fedenko A., Burov D., Aliev M., Petrochenko N.https://creativecommons.org/licenses/by/4.0https://sarbon.abvpress.ru/jour/article/view/255

Recurrence and metastasis make a big problem the treatment of patients with soft tissue extremely sarcoma. The appearance of distant metastases significantly reduces the overall survival. According to most publications, the same effect on the survival of the development of local recurrence is observed. Of particular interest is the group of patients with synchronous development of local and distant failure. The Department of General Oncology of Russian Cancer Research Center NN Blokhin in 2003-2008 have treated 27 patients with combined one-stage appearance of recurrent and metastatic process. The average time from onset of the primary tumor to the development of synchronous lesions was 11,1 months. The overall 3 year survival rate for this group of patients was 42%. We developed a staging system for patients with local recurrence of soft tissue sarcomas to form subgroups of patients with different rates of survival and rational treatment based on their prognosis.

Рецидивирование и метастазирование делают проблему лечения больных с саркомами мягких тканей опорно-двигательного аппарата чрезвычайно трудной. Появление отдаленных метастазов достоверно значительно уменьшает общую выживаемость. По данным большинства исследователей, так же влияет на выживаемость развитие локального рецидива. Особый интерес представляет группа пациентов с синхронным развитием локального и отдаленного поражения. В отделе общей онкологии РОНЦ им. Н.Н. Блохина РАМН в 2003-2008 годах находились на лечении 27 больных с сочетанным одномоментным появлением рецидивного и метастатического процесса. Среднее время от момента появления первичной опухоли до развития синхронного поражения - 11,1 мес. Общая 3 -летняя выживаемость данной группы пациентов - 42%. Продолжаются клинические разработки стадирующей системы для пациентов с локальным рецидивом сарком мягких тканей для формирования подгрупп больных с разными показателями выживаемости и рационального лечения на основе их прогноза.

soft tissue sarcomarecurrencemetastasisсаркома мягких тканейрецидивметастазАлиев М.Д. Современные подходы к лечению сарком мягких тканей. Практическая онкология. 2004, т. 5, № 4, с. 250-255.Pollock R.E., Karnell L.H., Menck H.R. et al. The National Cancer Data Base report on soft tissue sarcoma. Cancer. 1996, n. 15, 78 (10), p. 2247-2257.Le Vay J., O'Sullivan В., Catton C. et al. Outcome and prognostic factors in soft tissue sarcoma in the adult. Int. J. Radiat. Oncol. Biol. Phys. 1993, v. 27, p. 1091.Williard W.C., Hajdu S.I., Casper E.S. et al. Comparison of amputation with limb sparing operations for adult soft tissue sarcoma of the extremity. Ann. Surg. 1992, v. 215, p. 269.Davis A.M., Devlin M., Griffin A.M. et al. Functional outcome in amputation versus limb sparing of patients with lower extremity sarcoma: a matched case-control study. Arch. Phys. Med. Rehabil. 1999, v. 80, p. 615.Zagars G.K., Ballo M.T., Pisters P.W. et al. Surgical margins and reresection in the management of patients with soft tissue sarcoma using conservative surgery and radiation therapy. Cancer. 2003, v. 97, p. 2544.Peiper M., Zornig C., Schroder S. Reexcision of soft tissue sarcoma after inadequate initial operation. Brit. J. Surg. 1995, v. 82, p. 278.Pisters P.W., Leung D.H., Woodruff J. et al. Analysis of prognostic factors in 1,041 patients with localized soft tissue sarcomas of the extremities. J. Clin. Oncol. 1996, v. 14, p. 1679.Wylie J.P., O'Sullivan В., Catton C. et al. Contemporary radiotherapy for soft tissue sarcoma. Semin. Surg. Oncol. 1999, n. 17(1), p. 33-46.Issels R.D., Lindner L.Н., Verweij J. et al. Neo-adjuvant chemotherapy alone or with regional hyperthermia for localized high-risk soft-tissue sarcoma: a randomized phase 3 multicentre study. Tancet Oncol. 2010, Jun, 11 (6), p. 561-570.Grunhagen D.J., de Wilt J.H., Eggermont A.M. et al. Isolated limb perfusion with TNF-alpha and melphalan in locally advanced soft tissue sarcomas of the extremities. Recent Results Cancer Res. 2009, n. 179, p. 257-270.Trovik C.S., Gustafson P., Bauer H.C. et al. Consequences of local recurrence of soft tissue sarcoma: 205 patients from the Scandinavian Sarcoma Group Register. Acta Orthop. Scand. 2000, n. 71 (5), p. 488-495.Rosenberg S.A., Tepper J., Glatstein E. et al. The treatment of soft-tissue sarcomas of the extremities: prospective randomized evaluation of (1) limb-sparing surgery plus radiation therapy compared with amputation and (2) the role of adjuvant chemotherapy. Ann. Surg. 1982, n. 196 (3), p. 305-315.Brennan M.E., Hilaris B., Shiu M.H. et al. Local recurrence in adult soft-tissue sarcoma. A randomized trial of brachytherapy Arch. Surg. 1987, n. 122 (11), p. 1289-1293.Brennan M.E., Casper E.S., Harrison L.B. et al. The role of multimodality therapy in soft tissue sarcoma. Ann. Surg. 1991, n. 214, p. 328-338.Gustafson P., Rooser В., Rydholm A. Is local recurrence of minor importance for metastase in soft tissue sarcoma? Cancer. 1991, n. 67, p. 2083-2086.Potter D.A., Kinsella T., Glatstein E. et al. High-grade soft tissue sarcomas of the extremities. Cancer. 1986, n. 58, p. 190-205.Karakousis C.P., Proimakis C., Rao U. et al. Tocal recurrence and survival in soft-tissue sarcomas. Ann. Surg. Oncol. 1995, n. 3, p. 255-260.Singer S., Corson J.M., Gonin R. et al. Prognostic factors predictive of survival and local recurrence for extremity soft tissue sarcoma. Ann. Surg. 1994, n. 219, p. 165-173.Lewis J.J., Leung D., Heslin M. et al. Association of local recurrence with subsequent survival in extremity soft tissue sarcoma. J. Clin. Oncol. 1997, n. 15, p. 646-652.Stotter A.T, Ahern R.P., Fisher C. etal. The influence of local recurrence of extremity soft tissue sarcoma on metastases and survival. Cancer. 1990, n. 65, p. 1119-1129.Eilber F.C., Rosen G., Nelson S.D. et al. High-grade extremity soft tissue sarcomas: factors predictive of local recurrence and its effect on morbidity and mortality. Ann. Surg. 2003, n. 237 (2), p. 218-226.Eilber F.C., Rosen G., Nelson S.D. et al. High-grade extremity soft tissue sarcomas: factors predictive of local recurrence and its effect on morbidity and mortality. Ann. Surg. 2003, n. 237 (2), p. 218-226.Choong P.F., Gustafson P., Rydholm A. Size and timing of local recurrence predicts metastasis in soft tissue sarcoma. Growth rate index retrospectively analyzed in 134 patients. Acta Orthop. Scand. 1995, n. 66 (2), p. 147-152.Ramanathan R.C., A'Hern R., Fisher C. et al. Prognostic Index for Extremity Soft Tissue Sarcomas With Isolated Local Recurrence. Ann. Surg. Oncol.2001, n. 8 (4), p. 278-289.Guillou L., Coindre J.M., Bonichon F. et al. Comparative study of the National Cancer Institute and French Federation of Cancer Centers Sarcoma Group grading systems in a population of 410 adult patients with soft tissue sarcoma. J. Clin. Oncol. 1997, v. 15, p. 350.Palumbo R., Palmeri S., Antimi M. et al. Phase II study of continuous infusion high dose ifosfamide in advanced and/or metastatic pretreated soft tissue sarcomas. Ann. Oncol. 1997, v. 8, p. 1159.Jablons D., Steinberg S.M., Roth J. et al. Metastasectomy for soft tissue sarcoma. Further evidence for efficacy and prognostic indicators. J. Thorac. Cardiovasc. Surg. 1989, n. 97 (5), p. 695-705.Van Geel A.N., Pastorino U., Jauch K.W. et al. Surgical treatment of lung metastases: The European Organization for Research and Treatment of Cancer-Soft Tissue and Bone Sarcoma Group study of 255 patients. Cancer. 1996, n. 77 (4), p. 675-682.Casson A.G., Putnam J.В., Natarajan G. et al. Five-year survival after pulmonary metastasectomy for adult soft tissue sarcoma. Cancer. 1992, n. 69 (3), p. 662-668.Verazin G.T., Warneke J.A., Driscoll D.L. et al. Resection of lung metastases from soft-tissue sarcomas. A multivariate analysis. Arch. Surg.1992, n. 127 (12), p. 1407-1411.Putnam J.B., Roth J.A, Wesley M.N. et al. Analysis of prognostic factors in patients undergoing resection of pulmonary metastases from soft tissue sarcomas. J. Thorac. Cardiovasc. Surg. 1984, n. 87 (2), p. 260-268.Gadd M.A., Casper E.S., Woodruff J.M. et al. Development and treatment of pulmonary metastases in adult patients with extremity soft tissue sarcoma. Ann. Surg. 1993, n. 218 (6), p. 705-712.Trovik C.S., Bauer H.C., Berlin O. et al. Local recurrence of deep-seated, high-grade, soft tissue sarcoma: 459 patients from the Scandinavian Sarcoma Group Register. Acta Orthop. Scand. 2001, n. 72 (2), p. 160-166.Billingsley K.G., Burt M.E., Jara E. et al. Pulmonary Metastases From Soft Tissue Sarcoma: Analysis of Patterns of Disease and Postmetastasis Survival. Ann. Surg. 1999, n. 229 (5), p. 602-612.Patrikidou A., Domont J., Cioffi A., Le Cesne A. Treating soft tissue sarcomas with adjuvant chemotherapy. Curr. Treat. Options Oncol. 2011, Mar., 12 (1), p. 21-31.Casalil P.G., Blay J.Y. Soft tissue sarcomas: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Annals of Oncology 21 (Supplement 5). 2010, p. 198-203.Pervaiz N., Colterjohn N., Farrokhyar F. A systematic metaanalysis of randomized controlled trials of adjuvant chemotherapy for localized resectable soft-tissue sarcoma. Cancer. 2000, n. 113, p. 573-581.