Bone and soft tissue sarcomas, tumors of the skinBone and soft tissue sarcomas, tumors of the skinСаркомы костей, мягких тканей и опухоли кожи2219-46142782-3687Publishing House ABV Press257ArticlesСтатьиSIRVIVIN AND ITS ROLE IN MALIGNANT TUMORSСурвивин и его роль в патогенезе злокачественных опухолейКовалеваО. В.
Russian Federation
ovkovaleva@gmail.comШнейдерманА. Н.
Russian Federation
ЧевкинаЕ. М.
Russian Federation
KovalevaO. V.
Russian Federation
ShneydermanA. N.
Russian Federation
TchevkinaE. M.
Russian Federation
Российский онкологический научный центр им. Н.Н. Блохина РАМНN.N. Blokhin Russian Cancer Research Center Russian Academy of Medical Sciences1111201134627211012022Copyright ©; 2011, ., ., ., Kovaleva O.V., Shneyderman A.N., Tchevkina E.M.Copyright ©; 2011, Ковалева О.В., Шнейдерман А.Н., Чевкина Е.М., Kovaleva O., Shneyderman A., Tchevkina E.2011., ., ., Kovaleva O.V., Shneyderman A.N., Tchevkina E.M.Ковалева О.В., Шнейдерман А.Н., Чевкина Е.М., Kovaleva O., Shneyderman A., Tchevkina E.https://creativecommons.org/licenses/by/4.0https://sarbon.abvpress.ru/jour/article/view/257

During the last years study of survivin and other proteins from inhibitors of apoptosis family role in malignant transformation and tumor progression draws great attention. Survivin is expressed during the embryogenesis and is practically silent in all kinds of differentiated cells of adult organisms, but restarts its expression in the diversity of transformed cells types. Numerous attempts were made in order to use this protein as a diagnostic or prognostic marker as well as a target for anticancer therapy. Very recently published data evidences on survivin direct participation in the process of metastasis, what makes its study especially essential. Present review summarizes the modern knowledge, concerning the survivin structure and expression in human tumors. Special attention is drawn to its importance in different sarcomas development

В последние годы уделяется много внимания изучению роли сурвивина и других белков семейства ингибиторов апоптоза в процессах опухолевой трансформации и прогрессии. Сурвивин экспрессируется во время эмбриогенеза и практически отсутствует во всех дифференцированных клетках взрослого организма, однако его экспрессия возобновляется в опухолевых клетках различных типов. Были предприняты многочисленные попытки использования этого белка в качестве диагностического и прогностического онкомаркера, а также в качестве мишени противоопухолевой терапии. Совсем недавно появились сведения о возможном участии сурвивина непосредственно в процессе метастазирования, что делает вопрос его изучения еще более актуальным. В данном обзоре обобщены существующие на сегодняшний день представления о структуре, механизмах функционирования сурвивина и экспрессии данного гена в опухолях человека. Особое внимание уделено его значению при саркомах различного происхождения.

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