Bone and soft tissue sarcomas, tumors of the skinBone and soft tissue sarcomas, tumors of the skinСаркомы костей, мягких тканей и опухоли кожи2219-46142782-3687Publishing House ABV Press258ArticlesСтатьиTOWARDS INDIVIDUALIZED TREATMENT: PREDICTIVE FACTORS FOR CHEMOTHERAPY RELATED TOXIC EFFECTПерсонифицированная химиотерапия: маркеры предсказания токсичности противоопухолевых препаратовАбрамовМ. Е.
Russian Federation
ШвароваА. В.
Russian Federation
СтепановаЕ. В.
Russian Federation
e_stepanova@nm.ruAbramovM. E.
Russian Federation
ShvarovaA. V.
Russian Federation
StepanovaE. V.
Russian Federation
Российский онкологический научный центр им. Н.Н. Блохина РАМНN.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences1111201134737611012022Copyright ©; 2011, ., ., ., Abramov M.E., Shvarova A.V., Stepanova E.V.Copyright ©; 2011, Абрамов М.Е., Шварова А.В., Степанова Е.В., Abramov M., Shvarova A., Stepanova E.2011., ., ., Abramov M.E., Shvarova A.V., Stepanova E.V.Абрамов М.Е., Шварова А.В., Степанова Е.В., Abramov M., Shvarova A., Stepanova E.https://creativecommons.org/licenses/by/4.0https://sarbon.abvpress.ru/jour/article/view/258

Many drugs have been used for the treatment of cancer patients, but there is little information about how predictive factors can be used to aid treatment response and anticipate toxic effect related to anticancer treatment. There is a marked variability in drug handling between individual patients and this variability is based on genotyping individual patients. In this review we focus on genetic characteristics of xenobiotic-metabolizing enzymes. We also discuss the most valuable genetic predictive factors that relate to the toxic effects experienced by cancer patients treated with anticancer chemotherapy and the future prospects in this field of investigation.

В настоящее время для лечения онкологических заболеваний используется множество химиотерапевтических препаратов, однако мало известно о маркерах, предсказывающих эффективность и токсичность лечения. Как было показано, вариабельность в эффективности и токсичности химиопрепаратов у отдельных больных определяют их генотипические особенности. В обзоре описываются основные ферменты, метаболизирующие ксенобиотики, а также их значение для предсказания токсичности современных химиопрепаратов и перспективы дальнейших исследований.

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